The characteristics of 67 confirmed congenital syphilis cases reported to the surveillance system in Spain (2000-2010) were analyzed. The incidence rates ranged from 0.00 to 2.23 per 100,000 live births. Median age at diagnosis was 4 days. Hepatosplenomegaly was the most common clinical finding, although almost 60% of the cases were asymptomatic. Missed opportunities for congenital syphilis prevention through antenatal care were identified.
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