Abstract:The article presents data on the effectiveness of the impact of selenium on clinical and laboratory parameters of rheumatoid arthritis (RA) in patients with subclinical hypothyroid dysfunction (SHTD). Aim -to study the influence of selenium on the clinical and laboratory parameters in patients with RA and SHTD. Material and Methods -The study included 78 patients with RA and SHTD. All patients underwent a complete clinical and functional, instrumental and laboratory examination for RA and thyroid dysfunction. Sodium selenite was added to the standard therapy of rheumatoid arthritis drug. Results -Our study showed that RA patients with concomitant SHTD after treatment with a complex scheme, which included the preparation of sodium selenite, improved articular syndrome activity of rheumatoid inflammation, reduced levels of thyroid stimulating hormon (TSH) and antithyroidperoxidase (aTPO), reduced the number of patients with elevated levels of aTPO (p<0.05). Conclusion -The use of sodium selenite in the treatment of RA patients with SHTD is an effective method of correction of the articular syndrome, reducing the levels of markers of inflammation and autoimmune manifestations of the whole process, which is very important and necessary to prevent the progression of the disease.
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