Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction

Knyazeva, Antonina K.; Комарова, Е Б; Kuvichko, Natalia N.

doi:10.15275/rusomj.2016.0406

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…One report revealed that Se supplementation has an antioxidant effect as it upregulates selenoproteins and downregulates inflammation in autoimmune disorders [ 43 ]. The significance of Se supplementation, however, is still not distinct for the treatment of RA patients based on confusing data [ 44 , 45 ]. Moreover, the associated toxic effect of Se for the treatment of arthritis as an antioxidant supplement is debatable [ 46 ].…”

Section: Serum Selenium Status In Rheumatoid Arthritismentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

2021

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Rheumatoid arthritis (RA) is a common chronic inflammation-mediated disorder having systematic complications. RA triggers a self-directed inflammatory and immunological cascade that culminates in joint destruction. Though a range of treatment options are available, none of them are without adverse effects and this has led researchers to search for alternative solutions. Nanomedicine has emerged as a powerful therapeutic alternative, and selenium (Se) is an essential micronutrient trace element that has a crucial role in human health and disease. Selenium nanoparticles (SeNPs) derived from biological sources, such as plants, bacteria, fungi, and proteins, have exhibited remarkable candidate properties and toxicological profiles, and hence have shown potential to be used as antirheumatic agents. The potential of SeNPs can be attributed to the effect of functional groups bound to them, concentration, and most importantly to their nano range size. The antirheumatic effect of SeNPs is considerable due to its potential in amelioration of oxidative stress-mediated inflammation via downregulation of radical and nonradical species, markers of inflammation, and upregulation of inherent antioxidant defenses. The size and concentration impact of SeNPs has been shown in the subsequent antioxidant and anti-inflammatory properties. Moreover, the article emphasizes the role of these biogenic SeNPs as a notable option in the nanomedicine arena that needs to be further studied as a prospective remedial alternative to cure RA and medication-related adverse events.

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Section: Serum Selenium Status In Rheumatoid Arthritismentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

2021

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“…Clinical and experimental studies have shown that in pathogenesis of diseases such as cataracts and pancreatic cystic fibrosis is a scarce of a number of elements including selenium (Kumara & Priyadarsinib, 2014). It is not possible to say that selenium scarce is cause of chronic hepatitis or rheumatoid arthritis, but the severity of these diseases depends on element concentration in the body (Knyazeva et. al., 2016;Galal et.…”

Section: Ukrainian Journal Of Ecology 10(4) 2020mentioning

confidence: 99%

Selenium in natural environment and food chains. A Review

Sobolev¹,

Gutyj²,

Соболева³

2020

Ukr J Ecol

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The analytical review attempts to summarize the results of numerous scientific research conducted by scientists around the world on selenium scattering and accumulation in natural environment, with considerable attention paid to the concentration of this trace element in soils, natural waters and plants. It is shown that selenium content in agricultural products is caused by the processes of physico-chemical and biogenic migration of this element in the biogeochemical food chain. According to the modern classification of trace elements, which is based on their biological significance for living organisms, selenium belongs to the vital group or biogenic elements. As a biotic element, it has unique physicochemical and biochemical properties and with adequately absorbed into the human body has a positive effect on a number of physiological processes. Various research shows that the majority of the world population (except in some regions) today consumes less selenium with the food than necessary and its consumption decreases every year. Insufficient selenium intake in the human body (less than 15–30 μg/day) leads to the development one of the hypomicroelementosis – hyposelenosis. Selenium deficiency is considered as a possible etiological factor in some cardiovascular, cancer, osteoarticular and neurodegenerative diseases that threaten to human life. Providing the human body with selenium in optimal amounts is one of the important conditions of nutrition. A number of countries have developed recommended selenium intake standards for the adults, which range from 55 to 120 μg/day. We can calculate the physiological need for selenium in children and adolescents by extrapolation. The most safe and effective way to maintain the necessary level of selenium for the human body can be achieved only through the poultry and livestock products by mandatory introduction of premixes containing highly effective biologically available selenium forms into animal feed. This will ensure a relatively high level of trace element in meat, eggs, and milk and would eliminate the cases of toxicosis in human population due to buffer effect of animal tissues.

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Effects of Selenium Supplementation on the Indices of Disease Activity, Inflammation and Oxidative Stress in Patients with Rheumatoid Arthritis: a Randomized Clinical Trial

Zamani,

Taghvaee,

Akbari

et al. 2023

Biol Trace Elem Res

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Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction

Cited by 3 publications

References 6 publications

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

Selenium in natural environment and food chains. A Review

Effects of Selenium Supplementation on the Indices of Disease Activity, Inflammation and Oxidative Stress in Patients with Rheumatoid Arthritis: a Randomized Clinical Trial

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