Cerebral Palsy (CP) is a disabling condition that affects a child’s life and his/her family irreversibly. It is usually a non-progressive condition but improvement over time is rarely seen. The condition can be due to prenatal hypoxia, metabolic, genetic, infectious, traumatic or other causes. It is therefore a heterogeneous group that results in functional motor disability associated with different degrees of cognitive abnormalities. There are no treatments that can cure or even improve CP and the best available approach aims at functional, social and nutritional supportive care and counseling. In this paper, we report 17 sequential patients with CP treated with intrathecal administration of Bone Marrow Mononuclear Cells (BMMC). All patients had an uneventful post-injection course with 73% of the evaluable patients treated having a good response using the Gross Motor Function Classification System (GMFCS). The average improvement was 1.3 levels on the GMFCS with cognitive improvements as well.
and underwent the treatment with autologous stem cells. All Patients signed an informed consent after detailed discussion. The medium length of the preoperative discussion and explanation was 2 hours. Subjects enrolled in this study belonged to many categories and were subjected to various randomized protocols. All patients were treated with their own bone marrow derived stem cells after being divided into 4 groups: A, B, C and D (Table 1). A-Patients treated without pre-transplant preparation or posttransplant treatment. B-Patients treated with pre-transplant preparation. C-Patients treated without pre-transplant preparation but with post-transplant treatment. D-Patients treated with pre-transplant preparation and posttransplant treatment. The following neurological diseases were treated:
Temporomandibular joint (TMJ) disease is a type of degenerative musculoskeletal disorder that leads to morphological and functional abnormalities. It has a poorly understood progression with numerous independent and interrelated factors, which makes it difficult for the available treatment options to meet long-term demands.We present the case of a 37-year-old woman who suffered from excruciating pain in the right temporomandibular joint, associated with limited mandibular movement. She was found to have imaging features of TMJ disorder. She underwent the Regentime procedure which uses autologous bone marrowderived stem cells that are partially differentiated and redirected to the targeted tissue. Clinical follow-up showed total clinical recovery.
This article is a case report in which we exposed the results of a multiple sclerosis (MS) patient, treated with stem cells. The 51 year old female patient was presenting with 23 year history of primary progressive type of MS. Her disease was physically debilitating causing numerous permanent complications during its long history, where different medications were used with no improvement; MS was progressing uncontrollably.Autologous bone marrow derived stem cells were outsourcing the procedure of treatment (Regentime ® technique). This type of therapy was never previously used on such longstanding MS case and with such advanced impairment.Twelve main symptoms were studied and monitored during the post therapy care period. The follow up was done for 18 months before the publication of the results.We noticed a clear improvement at most levels, including a decrease in the headache, fatigue, hypertonia and dizziness. No regression was registered during the post-transplantation follow up period.We concluded that MS has positively responded to Regentime ® procedure stem cell therapy even in its advance longstanding stage. This positive response may be due to the pathophysiological stepping nature of MS, where better improvements are seen in newer calling-for-repair lesions as shown in a previous study.
Promising outcomes are shown in this case report using the Regentime procedure and autologous stem cells to treat spinal cord injury. The observed "First Show Phenomenon" provides valuable insights into the therapy's potential for spinal cord injury.
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