How to Maximize the Success of Stem Cell Autografts for Neuroregeneration

Abstract

and underwent the treatment with autologous stem cells. All Patients signed an informed consent after detailed discussion. The medium length of the preoperative discussion and explanation was 2 hours. Subjects enrolled in this study belonged to many categories and were subjected to various randomized protocols. All patients were treated with their own bone marrow derived stem cells after being divided into 4 groups: A, B, C and D (Table 1). A-Patients treated without pre-transplant preparation or posttransplant treatment. B-Patients treated with pre-transplant preparation. C-Patients treated without pre-transplant preparation but with post-transplant treatment. D-Patients treated with pre-transplant preparation and posttransplant treatment. The following neurological diseases were treated:

Treatment of Long Standing Multiple Sclerosis with Regentime Stem Cell Technique

“…In a previous study, Abi Chahine et al demonstrate that early treatment of neurodegenerative diseases is a key factor in the success of bone marrow derived stem cell transplantation [1]. In this case report, an acceptable positive result of ASCT in long standing multiple sclerosis is shown.…”

“…Multiple sclerosis (MS) is a progressive disease leading to degradation of the myelin sheath around central axons. Lesions are composed of areas of myelin and oligodendrocyte loss along with infiltrates of inflammatory cells, including lymphocytes and macrophages [1][2][3][4][5][6][7][8][9]. The degradation of myelin leads to disruption of the electrical neural communication, resulting in a wide range of clinical picture.…”

The Regentime stem cell procedure, successful treatment for a Charcot–Marie–Tooth disease case

“…19,20 The importance of the above-mentioned nucleotide supplementation, therefore, resides in its role in maximizing the efficacy of stem cell transplantation, thereby optimizing the overall outcome. 20 To the best of our knowledge, this is the first CMT case treated with autologous bone marrow-derived mononuclear stem cells globally. Our results underscore the potential of stem cell transplantation as a viable alternative approach in the treatment of CMT.…”

“…The administration of drugs containing nucleotides such as adenosine triphosphate, uridine monophosphate, and cytidine monophosphate is shown to favor myelinated fibers regeneration and promote functional recovery in the setting of peripheral nervous system damage. The mechanisms involve the stimulation of neural cell protein synthesis, nerve cell membrane synthesis, myelin sheath synthesis, and neurite sprouting 19,20 . The importance of the above‐mentioned nucleotide supplementation, therefore, resides in its role in maximizing the efficacy of stem cell transplantation, thereby optimizing the overall outcome 20 …”

“…The mechanisms involve the stimulation of neural cell protein synthesis, nerve cell membrane synthesis, myelin sheath synthesis, and neurite sprouting. 19,20 The importance of the above-mentioned nucleotide supplementation, therefore, resides in its role in maximizing the efficacy of stem cell transplantation, thereby optimizing the overall outcome. 20 To the best of our knowledge, this is the first CMT case treated with autologous bone marrow-derived mononuclear stem cells globally.…”