No abstract

The process of buying and selling via internet platforms is referred to as E-commerce. E-commerce has become a worldwide trend in recent years. People from all around the world have begun to purchase things online. Mobile commerce, money transfer, inventory management, and other aspects of electronic commerce are included. With only a few clicks, anyone can send anything to anyone, whether it's money or presents. In the future, electronic commerce might have a significant economic impact. Internet business will permanently alter the face of business. Furthermore, in the twenty-first century, E-commerce will transform banking. E-commerce has had a wide range of effects on the increasing global economy. First and foremost, it has impacted information technology and all economic sectors; above all, E-commerce has boosted global productivity growth and its impact are too high. They are able to determine the number of qualified people required to advance their country's information economy, as well as calculate the amount of investment required to provide businesses with internet access. Some benefits are now in a position to compare their economies to those of their international competitors, and there are numerous ways to boost productivity growth in present emerging markets.

Ab initio protein folding simulation largely depends on knowledge-based energy functions that are derived from known protein structures using statistical methods. These knowledge-based energy functions provide us with a good approximation of real protein energetics. However, these energy functions are not very informative for search algorithms and fail to distinguish the types of amino acid interactions that contribute largely to the energy function from those that do not. As a result, search algorithms frequently get trapped into the local minima. On the other hand, the hydrophobic–polar (HP) model considers hydrophobic interactions only. The simplified nature of HP energy function makes it limited only to a low-resolution model. In this paper, we present a strategy to derive a non-uniform scaled version of the real 20×20 pairwise energy function. The non-uniform scaling helps tackle the difficulty faced by a real energy function, whereas the integration of 20×20 pairwise information overcomes the limitations faced by the HP energy function. Here, we have applied a derived energy function with a genetic algorithm on discrete lattices. On a standard set of benchmark protein sequences, our approach significantly outperforms the state-of-the-art methods for similar models. Our approach has been able to explore regions of the conformational space which all the previous methods have failed to explore. Effectiveness of the derived energy function is presented by showing qualitative differences and similarities of the sampled structures to the native structures. Number of objective function evaluation in a single run of the algorithm is used as a comparison metric to demonstrate efficiency.

The  process  of  buying  and  selling  via  internet  platforms  is referred   to   as   E-commerce.   E-commerce   has   become   a worldwide  trend  in  recent  years.  People  from  all  around  the world have begun to purchase things online. Mobile commerce, money  transfer,  inventory  management,  and  other  aspects  of electronic commerce are included. With only a few clicks, anyone can send anything to anyone, whether it's money or presents. In the   future,   electronic   commerce   might   have   a   significant economic  impact.  Internet  business  will  permanently  alter  the face  of  business.  Furthermore,  in  the  twenty-first  century,  E-commerce will transform banking. E-commerce has had a wide range  of  effects  on  the  increasing  global  economy.  First  and foremost,   it  has  impacted  information  technology  and  all commercial  segments;  above  all,  E-commerce  has  boosted global production growth and its impact are too high. They are able to determine the number of professionals needed to develop their  country's  knowledge  economy,  as  well  as  compute  the quantity  of  investment  required  to  provide  businesses  with internet access. Some benefits are now in a position to compare their economies to those of their international competitors, and there are numerous ways to boost productivity growth in present emerging markets.