Pharyngitis, scarlet fever, and rheumatic fever are of the major infectious problems caused by Streptococcus Pyogen. Emergence of antibiotic-resistant strains makes such infection, its rheumatic valvular disease, and glomerulonephritis complications a serious clinical challenge especially in children. Its aims and objectives are, in a maneuver of overcoming S. Pyogen resistance and improve its response to antibiotic, a no steroidal anti-inflammatory drug NSAID is repurposed as antimicrobial against S. Pyogen. In intention to be combined with the classical antibiotic recommended by WHO guideline of care, the combination was assessed for its MIC and combination index against S. Pyogen. There was a significant synergism between Ampiclox-diclofenac (index ˂ 1) at P= 0.012 and Z score= 2.3 further confirmation of MIC folds of dilutions are to be assessed to obtain reasonable evidence.
Skin allergy is a widespread skin problem at the level of different ages, and it occurs when an irritant comes into contact with the skin, and immune system believes it is under attack, so it overreacts and sends antibodies to help fight invaders. Oral corticosteroids are used to treat the symptoms caused by all kinds of allergic reactions. Long-term use may cause many side effects, such as white water on the eyes, brittleness, weak bones, and stomach ulcers and an increase in blood sugar (glucose) and growth retardation for children. Oral corticosteroids may also worsen high blood pressure. This study has the advantage of designing and testing new topical formulas with standard kinetics and efficacy properties by combining tocopherol with glycolate in addition to antihistamines (phenylephrine hydrochloride and diphenhydramine) to form a Noder formula for the treatment of hypersensitivity. The current study was formulated to manufacture the Noder formula which was submitted to extensive investigations and analyzes by four important models. The results showed that the Noder formula has the ideal physical properties and the absorption is higher than the commercial formula and it has stability for a period of 24 months. The therapeutic efficiency in reducing the degree of redness and sensitivity was 60% compared to 56% in the commercial formula, as well as the clinical safety parameters are better from its comparison of general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula Noder compared to the commercial formula.
Background: Pharyngitis, scarlet fever, and rheumatic fever are of the major infectious problems caused by Streptococcus pyogen. Emergence of antibiotic-resistant strains makes such infection, its rheumatic valvular disease, and glomerulonephritis complications a serious clinical challenge especially in children. Aims and objectives:In a maneuver of overcoming S. pyogen resistance and improve its response to antibiotic, a no steroidal anti-inflammatory drug NSAID is repurposed as antimicrobial against S. pyogen. In intention to be combined with the classical antibiotic recommended by WHO guideline of care. The combination was assessed for its MIC and combination index against S. pyogen. Materials and Methods:A multidrug-resistant strain of S. pyogen was isolated from patients, suffering pharyngitis. The most serious isolate was cultivated for MIC determination of ampicloxdiclofenac combination in comparison with each alone to determine the combination index. Results and conclusions:There was a significant synergism between ampiclox-diclofenac (index ˂ 1) at P= 0.012 and Z score= 2.3 further confirmation of MIC folds of dilutions are to be assessed to obtain reasonable evidence. Recommendations:We recommended to further confirm the antistreptococcal effect of the combined ampiclox-diclofenac on more dilutions of MIC assay and to analyze data of this combination in patients with S. pyogen pharyngitis.
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