INTRODUCTIONThe color of normal skin comes from a mixture of pigments, of which the predominant is melanin. Pigmentation of the skin predominantly depends on the amount and type of melanin. The degree of skin vascularity, presence of carotene, and thickness of the stratum corneum are other factors that play a role.¹ A blemishless skin is the desire of all human beings. Psychological impact ofpigmentary imperfection provides the impetus for an understanding of pathology of post inflammatory hypopigmented disorders. They are the commonest presentations in patients attending Dermatology OPD. Hence there is a need to study various clinical presentations & histopathology of such lesions. ABSTRACT Background:The objective of the study was to study the various etiologies and ascertain different clinicalpresentations of post-inflammatory hypopigmented lesions. Age and sex distribution, socio economic status, seasonal incidence, most common to rare variants amongst all conditions and to correlate them histopathologically. Methods: 100 patients presenting with Post-inflammatory hypopigmented lesions were selected and detailed history and examination was done. Lab investigations and histopathology was done in those cases. Results: Among the various causes of post-inflammatory hypopigmentation, commonly observed conditions were Pityriasis versicolor, mechanical injuries, Pityriasis alba, burns, leprosy, allergic contact dermatitis, morphoea, discoid lupus erythematosus, psoriasis and Steven's Johnson syndrome. Most common age group affected was in 21-30 years of age. Males (60%) were more than females (40%). People of lower socioeconomic status (55%) presented with post-inflammatory hypo pigmented lesions commonly. History of hypopigmentation ranged from 0-6 months in majority of cases. Upper limbs, trunk and face and neck regions were the most common sites involved. Commonest etiology amongst all cases was pityriasisversicolor, followed by mechanical injuries, PityriasisAlba and burns. Clinical diagnosis correlated with histopathology in these cases. Conclusions:The study concluded that post-inflammatory hypopigmented lesions presented with various manifestations, more common in young, male adults, common in people of lower socioeconomic group. Upper limbs, trunk and face and neck are the common sites involved and histopathology correlated with clinical diagnosis in many cases.
Background: The aim of the study was to conduct the monitoring, detection, assessment and prevention of corticosteroid induced adverse drug reactions in dermatological diseases.Methods: Patient demographic details, past medical, medication history, lab investigations, allergic history were collected patient were followed and data collected every 1 month from the day of patient recruitment. The 1st, 2nd and 3rd follow ups were done, analysis of ADRs was done by using scales at each follow-up. In statistical analysis, data was articulated in percentage. A prospective, interventional study were designed.Results: In present study, author have recruited 40 subjects of which authors categorized ADRs based on different systems. In that 14 (56%) ADRs were identified in cardiovascular system and it was the majorly affected organ system followed by endocrine system 4 (16%). In 40 patients, 25 patients developed ADRs. In these male patients was 14 (56%) and female patients was 11 (44%). In 25, the majorly developed ADR was hypertension 13 (52%) followed by DM 4 (16%). In all ADRs majorly developed due to use of Prednisolone 17 (42%). The developed ADRs majorly in the age group of 41-50 (48%) years followed by 31-40 (16%) and 51-60 (16%).Conclusions: The study found that incidence of ADRs in males was higher than that of the females. Prednisolone was the most common drug associated with the ADRs. Majority of reported ADRs were managed by giving suitable interventions and most of the patients recovered after management.
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