The synthesis of some novel 4‐azaindole‐1,2,4‐oxadiazole hybrids (5 a–5 q) from the reaction between 1H‐pyrrolo[3,2‐b]pyridine‐3‐carbonitrile and readily available aromatic carboxylic acids using was described herein. All these hybrids were evaluated for their in vitro anticancer activity against three human cancer cell lines namely A375 (melanoma), MCF7 (breast) and A549 (lung) using MTT assay and outcomes revealed that three compounds like 5 c, 5 f and 5 m displayed superior inhibitory activities against all the cell lines than the standard. In those, predominantly, the compound 5 m showed outstanding activity in MCF‐7 cell line possessing IC50 values 0.48 μM. In addition, the in silico studies of three potent compounds 5 c, 5 f and 5 m were carried out to identify the interactions against EGFR receptor and found that the energy calculations were in good agreement with the obtained IC50 values. Furthermore, the compounds 5 c, 5 f and 5 m exhibited promising inhibitory activity against tyrosine kinase EGFR. Among them, the compounds 5 f and 5 m displayed superior activity against tyrosine kinase EGFR when compared with the standard Erlotinib.

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Catalyst efficacy of in situ generated Pd-nanoparticles in the regioselective one-pot synthesis of substituted pyrazoles and isoxazoles via sequential coupling-cyclization methodology in environmentally benign medium is described.

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A stoichiometric C–H activation/decarbonylation of salicylaldehyde by [(η6‐p‐cymene)RuCl2]2 gave a carbonyl derivative [(η6‐p‐cymene)RuCl(CO)(Ph‐O)] (1) without the use of CO gas. A variety of polar phosphines were then incorporated into compound 1 to give new RuII cationic catalysts, [(η6‐p‐cymene)Ru(CO)(Ph‐O)L]BF4 (2–8). These were used to catalyse the hydrothiolation of alkynes with a range of thiols in aqueous THF to give anti‐Markovnikov E‐linear vinyl sulfides in high yields.

Ag(I)/organo‐NHC catalyst pair (Lewis acidic/basic) delivered from labile Ag(I)‐NHC complex in ethanol has shown synergistic effect to catalyze the one‐pot four‐component reaction of isatins, malononitrile, cyclic ketones and ammonium acetate to produce new series of spirooxindole‐1,4‐dihydropyridine scaffolds. Carbene trapping from pre‐synthesized Ag(I)‐NHC in the form of zwitterionic CS2‐NHC adduct in ethanol provides evidence for the proposed synergistic catalysis. Besides, preliminary results of anticancer activity of these new spirooxindole‐1,4‐dihydropyridines are also presented.