ABSTRAKDiabetes mellitus (DM) merupakan penyakit gangguan metabolisme yang ditandai dengan meningkatnya kadar glukosa darah (hiperglikemia) akibat gangguan sekresi insulin dan atau meningkatnya resistensi insulin. Terapi ekstrak metanol biji mahoni (Swetenia mahagoni Jacq) merupakan salah satu pengobatan alternatif penyakit DM. Penelitian ini dilakukan untuk membuktikan pengaruh pemberian terapi ekstrak metanol biji mahoni terhadap kadar insulin, ekspresi TNF-α dan perbaikan jaringan pankreas pada tikus hasil induksi Multiple Low Dose-Streptozotocin (MLD-STZ) dosis 20 mg/kgBB selama 5 hari berturut-turut. Tikus diukur kadar glukosa darah dengan menggunakan glukometer digital dan dinyatakan DM bila kadar glukosa darahnya ≥300 mg/dl. Penelitian ini menggunakan 25 ekor tikus putih (Rattus novergicus) jantan galur wistar yang dibagi menjadi 5 kelompok yaitu kelompok 1 kontrol negatif, kelompok 2 kontrol positif, kelompok 3, 4 dan 5 tikus hasil induksi MLD-STZ serta masing-masing diberikan terapi ekstrak metanol biji mahoni dosis 100; 250 dan 400 mg/kgBB selama 7 hari. Hasil penelitian menunjukkan bahwa pemberian terapi ekstrak metanol biji mahoni dosis 100; 250 dan 400 mg/kgBB pada tikus hasil induksi MLD-STZ menunjukkan penurunan kadar glukosa darah berturut-turut sebesar 55,47%; 81,01% dan 73,63%, peningkatan kadar insulin sebesar 78,38%; 275,68% dan 145,95%, penurunan ekspresi TNF-α sebesar 30,34%; 67,28% dan 49,91%, serta perbaikan kerusakan jaringan pankreas pada penurunan derajat insulitis (p<0,05). Berdasarkan penelitian ini dapat disimpulkan adanya pengaruh terapi ekstrak metanol biji mahoni terhadap kadar insulin, ekspresi TNF-α dan kerusakan jaringan pankreas tikus hasil induksi MLD-STZ. Pengaruh terapi tersebut optimal pada pemberian biji mahoni dosis 250 mg/kgBB. Kata Kunci: Ekstrak metanol biji mahoni, ekspresi TNF-α, insulin, kerusakan jaringan pankreas, MLD-STZ ABSTRACT Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of Methanolic Swetenia mahagoni Seed Extracts is an alternative treatment for DM. The objective of this research is to prove the effect of extract of Swetenia mahagoni Jacq to increasing of insulin, decreasing Tumor Necrosis Factor (TNF-α) expression and repair pancreatic tissue damage of rat result Multiple Low Dose-Streptozotocin (MLD-STZ )induced dose of 20 mg/kg weight for 5 days successively. Blood glucose of rat was measured using digital glucometer and categorized as DM if it is >300 mg/dL. This research used 25 wistar strained white rat (Rattus norvegicus
Ampas tahu merupakan limbah dalam bentuk padatan dari bubur kedelai yang masih memiliki kandungan protein yang sangat tinggi dan banyak mengandung serat serta mudah diperoleh. Hal tersebut dapat dikembangkan menjadi suatu bentuk produk biskuit sebagai makanan tambahan anak sekolah (PMT-AS). Tujuan dari penelitian ini adalah menganalisis pengaruh proporsi tepung terigu dan tepung ampas tahu dengan kandungan protein dan serat serta daya terima pada biskuit. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 kali replikasi dengan masing – masing perlakuan yaitu P0 (100 : 0), P1 (65 : 35), P2 (60 : 40), P3 (55 : 45). Metode pengujian kadar protein dengan metode Kjehdal dan serat dengan metode gravimetri. Metode pengujian organoleptik dengan metode Hedonic Scale Scoring. Analisis statistik yang digunakan untuk daya terima adalah uji Friedman sedangkan untuk kadar protein dan serat menggunakan analisis One Way ANOVA. Hasil penelitian didapatkan berpengaruh tidak nyata antara proporsi tepung terigu dan tepung ampas tahu terhadap kadar protein biskuit (p=0.168). Berpengaruh secara nyata antara proporsi tepung terigu dan tepung ampas tahu dengan kadar serat biskuit (p=0.000). Berpengaruh secara nyata antara proporsi tepung terigu dan tepung ampas tahu dengan daya terima warna, aroma, tekstur biskuit (p=0.002), (p=0.003) dan (p=0.007). Berpengaruh tidak nyata antara proporsi tepung terigu dan tepung ampas tahu dengan daya terima rasa biskuit (p=0.377). Perlakuan terbaik dari segi kadar protein adalah perlakuan P2 dengan nilai rata-rata 10.3% perlakuan terbaik dari segi kadar serat adalah perlakuan P2 dengan nilai rata-rata 3.53%. dan perlakuan terbaik tingkat kesukaan dengan skor suka pada (warna,aroma,tekstur,rasa) adalah perlakuan P2. Kata Kunci: pengaruh proporsi tepung terigu, ampas tahu, protein, serat daya terima biskuit
Elderly tends to face health problems caused by a decrease in body functions due to aging. One of the most health problems experienced by elderly is in cardiovascular system like hypertension. Factors influenced blood pressures are overweight, less physical activity, and eating high sodium foods. This study aimed to determine the relationship between sodium intake, frequency and duration of physical activity to blood pressure of elderly at Tresna Werdha Budi Sejahtera and Bina Laras Budi Luhur nursing homes in Banjarbaru. This research used cross sectional design. Pearson test were applied (α = 0.05). This study involved 65 elderly aged 60-74 years, 28 males (43%) and 37 females (57%). Data were collected using questionnaires. Nutrient contents were obtained using 1x24 hour food recall for 2 days included weekend. The result of Pearson test indicated that there was a significant positive correlation between sodium intake with systolic (p <0.05) and diastolic (p <0.05) levels. Moreover, there was a significant negative correlation between the frequency of physical activity with systolic (p < 0.05) and diastolic (p <0.05) levels; there was a significant negative correlation between physical activity duration and sistolic blood pressure (p<0.05). However, there was no significant correlation between physical activity duration and diastolic blood pressure. It was suggested that health workers should improve health promotion program using posters and do counseling about healthy lifestyles, i.e. suggesting people to avoid high sodium foods and do physical activity regularly.
Tilapia and spinach are foods high in protein and iron nutrients. Pempek is a food interspersed that is favored by all circles, especially adolescent. This study aims to find out the protein content, iron and acceptability (color, aroma, texture and taste) tilapia and spinach pempek as a food interspersed adolescent girls to prevent anemia.This study is an experimental study with a Complete Randomized Design that is with the proportion of tilapia and spinach consists of 4 treatments namely P0= 100%:0%, P1= 90%:10%, P2= 80%:20% and P3= 70%:30%. The protein content was tested by Kjedahl method and the iron content was tested with visionary spectrometry method. While statistical analysis of protein and iron content using One Way Anova test and acceptability using Friedman analysis. The results of this study are known that the average protein content is P0 which is 7.11% and the highest iron is P3 which is 17.56 mg /100 g.The results of statistical analysis showed there is an influence on the protein content in tilapia and spinach pempek p=0,000, there is an influence on the iron content in tilapia pempek and p=0.000<α, Proportion of tilapia and spinach is shown to have an influence on the acceptability (color, aroma, texture) in tilapia and spinach boiled pempek and acceptability (color, aroma, taste and texture) in tilapia and spinach fried pempek because p<0.05. And proved to have no influence on the acceptability of texture on tilapia and spinach boiled pempek because p>0.05. Pempek in the first treatment (P1) can be an alternative to eating adolescent girls interspersed to prevent anemia by consuming 136 grams.
Toddlers are a group that is prone to anemia. One of the efforts to prevent anemia in a toddler is by fulfilling nutrients such as protein and iron. Chicken and haliling are high protein and iron foods that can be used to prevent anemia in toddlers. This study aims to determine the level of protein, iron and hedonic scaling (color, aroma, texture, and taste) of chicken nuggets and haliling as a snack for a toddler to prevent anemia. The method used in this study was a pure experimental design with a completely randomized design (CRD) with 4 treatments and 3 replications with the proportions of chicken and haliling P0 (100%:0%), P1 (90%:10%), P2 (80%:20%), P3 (70%:30%). The research panelists consisted of 25 untrained panelists. Analysis of protein content using the Kjeldahl method and iron using the visible spectrophotometric method, analysis of protein content data using Kruskal Wallis, iron using One Way Anova and hedonic scaling using Friedman. The results showed that there was an effect of the proportion of chicken and haliling on protein content (p=0.016), iron (p=0.001), color hedonic scaling (p=0.004), aroma (p=0.001), texture (p=0.001) and taste (p=0.001) on nuggets. The highest protein content at P3 was 11.27 g/100 g, the highest iron content at P3 was 2.2 mg/100 g, and the hedonic scaling for nuggets containing the proportions of chicken and halilings for color, aroma, texture, and taste was highest at P1 with an average of 3.2, 2.95, 3.25 and 2.85
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.