Botox injection is the best known as a group of medication that uses various forms of Botulinum toxin A to temporarily paralyze muscle. It primarily reduces the appearance of some facial wrinkles and it is known as Botox Cosmetic. It is a popular treatment among people who want to achieve younger look. A 34-year-old female collapsed at beauty salon soon after receiving Botox injection. Although resuscitation was done in the emergency unit, hospital, she could not be revived and succumbed to death. This case report highlights the rare case of sudden death after Botox injection. We would like people to raise the awareness of unexpected occurrence after Botox injection while they make themselves beautify.