An autoimplantation technique was adopted in the treatment of 50 cases of anogenital warts and was compared with the conventionally used podophyllin regimen in a matched group of 50 patients. They were assessed with 15 untreated subjects in a control group for the rate of clinical cure after 6 weeks, recurrence after 1 year follow up and for humoral and cell mediated immune responses before and after treatment. In the podophyllin group, 70% of patients were cured after 6 weeks while in autoimplantation, only 44% of patients were cured, and none in the control group had natural remission of warts without any treatment. After 1 year all the cured cases (100%) that completed follow up had recurrence of warts with podophyllin treatment, while none had recurrence of lesions in the autoimplantation group. Results of the humoral and cell mediated immune (CMI) response studies revealed that autoimplantation technique significantly augmented both humoral and CMI responses while there was not significant change in the immune status after podophyllin treatment (P > 0.001).
Objectives: Relationship amongst celiac disease (CD) and lung diseases has been discussed in the past. Studies have documented that CD is linked with lung diseases. CD has also been described to complement asthma. This study was planned to document the prevalence of asthma as well as allergic rhinitis in confirmed cases of CD and conducted pulmonary function testing in children aged 5 to 16 years while comparing them with controls. Study Design: Cross sectional study. Setting: Department of Pediatrics Medicine, Children Hospital Chandka Medical College / Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. Period: From 1st January 2018 to 30th June 2018. Material & Methods: We enrolled 50 confirmed cases of CD along with 100 controls with non specific abdominal pain. All were aged 6 to 16 years, of both genders. Demographics as well as questions related to asthma and allergic rhinitis were noted. Results: Amongst a total of 150 children, 61 (40.7%) male and 89 (59.3%) female. Overall mean age amongst children was 9.80 years with standard deviation of 2.6 years. A total of 40 (26.7%) children who had weight below the 3rd percentile while 36 (24.0%) had height below the 3rd percentile. Most children, 82 (54.7%) had normal BMI. Weight below the 3rd percentile and height below the 3rd percentile were of statistical significance as children with a weight and height below the 3rd percentile were significantly higher in the CD group (P = 0.026 and P = 0.005, respectively). Asthma and allergic rhinitis characteristics were not much different between the two groups (p > 0.05). The Pulmonary function test (PFT) results showed that 7 (14.0%) cases with CD and 12 (12.0%) controls had obstructive pulmonary changes (p > 0.05). Conclusion: Rates of Asthma and allergic rhinitis in children having CD were not significantly higher in comparison to controls. No linkage between asthma and allergic rhinitis symptoms was seen children having CD.
ABSTRACT Objectives To compare mean platelet volume (MPV) in neonates with and without sepsis. Study design Cross sectional descriptive study. Place & duration of study Neonatal Unit, Department of Paediatrics, Military Hospital, Rawalpindi from 2nd July 2017 to 22nd January 2018. Material and Methods 140 neonates, of either gender with ages between 0-28 days, suspected of neonatal sepsis presenting with any two of the signs: core body temperature of > 38.5°C or < 36°C at time of presentation, pulse rate beyond the range of 100-200 beats/minute, leukocyte count beyond the range of 4000 to 30,000/mm3 or > 10% immature neutrophils on peripheral smear, tachypnea (>60 breaths/minute) and oxygen saturation (< 90%) on pulse oximeter, were included; while neonates having taken > 2 doses of antibiotics in last 48 hours as per history and clinical record were excluded. 3ml of blood was drawn and sent for culture, while another 3ml of blood sent for peripheral smear and MPV. All the data along with demographic details of the patients were noted. Same laboratory was used for all samples and the peripheral smear was done by the same pathologist each time to eliminate bias. Results 31 neonates were culture positive for neonatal sepsis. Mean MPV(fl) was 7.31+0.92(fl). MPV was 8.52+0.51(fl) in septic neonates and 6.97+0.70(fl) in neonates without sepsis. The p value was significant (0.0001). Conclusion MPV was significantly raised in patients with sepsis. KEYWORDS Neonates, Sepsis, Mean Platelet Volume
Hepatic portal venous gas (HPVG) is usually associated with necrotizing enterocolitis or bowel ischemia in infants but it's a rare finding with hypertrophic pyloric stenosis (HPS). In such cases, portal venous gas is a benign incidental finding and does not advocate any delay in the surgical treatment. We report this atypical case of 3 weeks old male infant with HPS having portal venous gas that was detected on abdominal ultrasound. Our patient with a history of term delivery was brought to the pediatric department of Combined Military Hospital Lahore on 25th of November, 2013 with complaints of vomiting and constipation for the last 4 days. Physical examination showed that the infant was lethargic and mildly dehydrated with soft and non-tender abdomen. Baseline blood tests revealed metabolic alkalosis with hemoglobin and total leukocyte count within normal limits. Plain xray abdomen showed a distended stomach with no signs of gut obstruction. Abdominal ultrasonography revealed a severely thickened and lengthened pylorus suggestive of hypertrophic pyloric stenosis. Moreover, ultrasound also showed multiple echogenic foci diffusely involving the both lobes of otherwise normal sized liver. Moving air bubbles were also detected in the extra and intra hepatic portal and splenic veins on dynamic scanning confirming the presence of portal venous gas. The infant underwent Ramstedt's pyloromyotomy for HPS. The infant showed a steady recovery and ultrasonography performed at 2nd post op day detected no signs of gas within the hepato portal veins.
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