With a micro-electro-mechanical system (MEMS) mirror, we successfully developed a miniaturized epi-third-harmonic-generation (epi-THG) fiber-microscope with a video frame rate (31 Hz), which was designed for in vivo optical biopsy of human skin. With a large-mode-area (LMA) photonic crystal fiber (PCF) and a regular microscopic objective, the nonlinear distortion of the ultrafast pulses delivery could be much reduced while still achieving a 0.4 microm lateral resolution for epi-THG signals. In vivo real time virtual biopsy of the Asian skin with a video rate (31 Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use.

No abstract

Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death at the cellular level.

Wave propagation and thickness vibrations in two−layered piezoelectric plates are investigated by the three−dimensional theory of piezoelectricity and approximate theories. Piezoelectric materials of hexagonal symmetry are considered. The sixfold axes of the materials are assumed to be parallel or perpendicular to the plate. Dispersion curves and frequencies for thickness vibrations are presented. The electromechanical coupling effect is examined and

Acoustic surface waves propagating around a piezoelectric cylinder with metallic overlays are investigated. The piezoelectric core is assumed to possess the hexagonal symmetry, and the layer is electrically shorted. The dispersion equation is derived. Numerical results for the phase velocities, the displacement, and potential profiles are presented for different layer materials with various thicknesses. It is found that the thickness of the gold and chromium has a substantial effect on the dispersion, while in the case of aluminum layers little influence is observed. An asymptotic expansion for the dispersion equation is also derived and is found to yield results in good agreement with the exact solution.

We report what we believe to be the first demonstration of a facile approach with controlled geometry for the production of crystal-core ceramic-clad hybrid fibers for scaling fiber devices to high average powers. The process consists of dip coating a solution of polycrystalline alumina onto a high-crystallinity 40-μm-diameter Ti:sapphire single-crystalline core followed by thermal treatments. Comparison of the measured refractive index with high-resolution transmission electron microscopy reveals that a Ca/Si-rich intragranular layer is precipitated at grain boundaries by impurity segregation and liquid-phase formation due to the relief of misfit strain energy in the Al2O3 matrix, slightly perturbing the refractive index and hence the optical properties. Additionally, electron backscatter diffractions supply further evidence that the Ti:sapphire single-crystalline core provides the template for growth into a sacrificial polycrystalline cladding, bringing the core and cladding into a direct bond. The thus-prepared doped crystal core with the undoped crystal cladding was achieved through the abnormal grain-growth process. The presented results provide a general guideline both for controlling crystal growth and for the performance of hybrid materials and provides insights into how one might design single-mode high-power crystal fiber devices.

This paper proposes the design of a vertical slot waveguide-based optical ring resonator on a silicon photonic platform with minimized polarization mode dispersion (PMD) in the presence of waveguide dispersion over a wide band. Slot waveguides provide more degrees of freedom in the design, thereby achieving the minimum PMD over the communication wavelengths. The minimum PMD leads to nearly identical accumulated phase in the optical ring resonator for quasi-TE and TM modes, and thus the resonant wavelength mismatch between the quasi-TE and TM modes can be minimized from 1510 to 1590 nm.

We propose and demonstrate a facile approach for ultraviolet-visible broadband generation from a sapphire crystal core-borosilicate glass cladding hybrid fiber using a laser-heated pedestal growth technique. Considerable formation of F- and F(2)-type color emitters is effectively facilitated by Ti(4+) ions and Al(3+) vacancies, retaining efficient luminescence and high crystallinity of the sapphire core. These color centers intensify the ultraviolet, blue, and green emissions at 370, 450, and 540 nm, whereas the 650-nm red emission is contributed by Cr(3+) in the octahedral sites of the corundum structure. Over 1-mW white light with an optical-to-optical efficiency of up to nearly 5% and 1931 Commission International de l'Eclairage chromaticity coordinate of (0.287, 0.333) is achieved under 325-nm excitation.