Objective: The goal of the study was to formulate and characterized the pH stimuli sensitive based hydrogels for the effective treatment of infected eye. Method: Simple method of preparation was adapted. Result: The optimized formulations was undergone the characterization studies such as XRD spectrum analysis, FTIR analysis, Gelling capacity, Drug content, Determination of viscosity, surface tension of the optimized formulations, DSC analysis, in-vitro release study of the optimized formulations, Ex-vivo release studies of best formulation and stability studies. The pre-formulation studies confirm the drug and polymer are compatible with each other. The F5 formulation showed the maximum percentage of drug release around 97.08% in drug release study. The ex-vivo study showed 95.57% of drug release for the period of 7 hours. Further, the optimized formulations were most stable in room temperature when compared to higher temperature. Conclusion:The prepared formulations of pH based hydrogels were optimized; developed formulations are used as treatment for ocular drug delivery system with increase in precorneal time, reduced frequency of the dosage and to achieve the patient compliance.Key words: Hydrogels, Viscosity, Ex-vivo study, Stimuli, Sensitive, Gelling Capacity. Key Messages: To prepare the pH based in-situ gel the transition of sol to gel plays vital role in the smart drug delivery system. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Aim/Background: A scaffold is a wound dressing material which can be fabricated in the shape of the tissue that we want to restore in our body depending upon their structural and functional requirements. Chitin is the carbon-based resource having boundless activity as a wound healing accelerator. By the addition of silver nanoparticles, the wound remedial ability and antiseptic activity of chitin can be boosted. Materials and Methods: Chitin was obtained from the crab shell by demineralization, heating (300°C) and dehydration. 1g, 2g, 3g, 4g and 5g of chitin was accurately weighed and formulated into five different formulations with Calcium chloride/methanol solvent. The formulated hydrogel was clarified by Whatman filter paper. Then the nanosilver solution was prepared, characterized by the pale yellow colour and added to the formulations. Further, it was lyophilized to obtain chitin hydrogel/nanosilver fused scaffold formulations namely S1, S2, S3, S4 and S5. All the five formulations were characterized for weight loss, swelling ability, porosity measurement and surface analysis. Results and Conclusion: The augmented formulation i.e., S5 was subjected to further characterization studies such as FT-IR analysis, optical microscopy, SEM, TEM, XRD, Zeta potential and in-vitro antibacterial activity. From this research, it was concluded that the chitin hydrogel nanosilver fused scaffold is a viable alternative to existing conventional dosage forms which lead to improved bioactivity and a promising biomaterial for wound dressing applications in case of administration affords to result in better patient compliance and cost-effective therapy in the field of biomedical application.
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