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Background COVID-19 is a novel virus that affects the upper respiratory tract, as well as the lungs. The scale of the global COVID-19 pandemic, its spreading rate, and deaths are increasing regularly. Computed tomography (CT) scans can be used carefully to detect and analyze COVID-19 cases. In CT images/scans, ground-glass opacity (GGO) is found in the early stages of infection. While in later stages, there is a superimposed pulmonary consolidation. Methods This research investigates the quantum machine learning (QML) and classical machine learning (CML) approaches for the analysis of COVID-19 images. The recent developments in quantum computing have led researchers to explore new ideas and approaches using QML. The proposed approach consists of two phases: in phase I, synthetic CT images are generated through the conditional adversarial network (CGAN) to increase the size of the dataset for accurate training and testing. In phase II, the classification of COVID-19/healthy images is performed, in which two models are proposed: CML and QML. Result The proposed model achieved 0.94 precision (Pn), 0.94 accuracy (Ac), 0.94 recall (Rl), and 0.94 F1-score (Fe) on POF Hospital dataset while 0.96 Pn, 0.96 Ac, 0.95 Rl, and 0.96 Fe on UCSD-AI4H dataset. Conclusion The proposed method achieved better results when compared to the latest published work in this domain.

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Lung and colon cancers are among the leading causes of human mortality and morbidity. Early diagnostic work up of these diseases include radiography, ultrasound, magnetic resonance imaging, and computed tomography. Certain blood tumor markers for carcinoma lung and colon also aid in the diagnosis. Despite the lab and diagnostic imaging, histopathology remains the gold standard, which provides cell-level images of tissue under examination. To read these images, a histopathologist spends a large amount of time. Furthermore, using conventional diagnostic methods involve high-end equipment as well. This leads to limited number of patients getting final diagnosis and early treatment. In addition, there are chances of inter-observer errors. In recent years, deep learning has shown promising results in the medical field. This has helped in early diagnosis and treatment according to severity of disease. With the help of EfficientNetV2 models that have been cross-validated and tested fivefold, we propose an automated method for detecting lung (lung adenocarcinoma, lung benign, and lung squamous cell carcinoma) and colon (colon adenocarcinoma and colon benign) cancer subtypes from LC25000 histopathology images. A state-of-the-art deep learning architecture based on the principles of compound scaling and progressive learning, EfficientNetV2 large, medium, and small models. An accuracy of 99.97%, AUC of 99.99%, F1-score of 99.97%, balanced accuracy of 99.97%, and Matthew’s correlation coefficient of 99.96% were obtained on the test set using the EffcientNetV2-L model for the 5-class classification of lung and colon cancers, outperforming the existing methods. Using gradCAM, we created visual saliency maps to precisely locate the vital regions in the histopathology images from the test set where the models put more attention during cancer subtype predictions. This visual saliency maps may potentially assist pathologists to design better treatment strategies. Therefore, it is possible to use the proposed pipeline in clinical settings for fully automated lung and colon cancer detection from histopathology images with explainability.

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