Purpose of the study. To study the balance of fatty acid spectrum of oral lipids as a marker of oxidant-antioxidant stress in patients with generalized parodontitis with anorexia nervosa. Materials and methods. The study metabolic disorders of fatty acids oral fluid was conducted in 28 patients with GP, primary-I, I–II degree, chronic course associated with anorexia nervosa, (average age 26 ± 3,8) – the main group (M). The comparison group (C) included 23 patients with GP, primary-I, I–II degree, chronic course with no eating disorders. The control group consisted of 25 healthy individuals of the same age category. Patients' oral fluid was used as the object of study. In the spectrum of fatty acids of lipids of the oral fluid, the 9 most informative fatty acids were identified: myristic C 14:0,pentodecane C 15:0, palmitic C 16:0, margarine C 17:0,stearic C 18:0, oleic C 18:1, linoleum C 18:2, linolen C 18:3, arachidone C 20:4. Quantification of the spectrum of lipid fatty acids was performed by the method of normalization of planes and determined the proportion of acids in percents. Results. The fatty acid content of the oral fluid of patients in the main group was significantly different from the control parameters. 12% in patients with anorexia nervosa significantly increased the amount of saturated fatty acids by increasing the content of palmitic acid (C 160) and reducing stearic acid (C 18:0) by 2 times compared with control.It was established that the sum of unsaturated fatty acids was reduced by 2 times due to polyunsaturated fatty acids, and this level was significantly reduced by 2 times in comparison with control group due to 3 times reduction of linoleum fatty acid (C 18:2), linolenic fatty acid (C 18:3) 2-fold and unreliable increase in arachidone fatty acid (C 20:4), in comparison with the control, which in our opinion, reflects disturbance of the oxidant-antioxidant balance and is a marker of stress as an indicator of endogenous intoxication in patients with GP and anorexia nervosa.In patients with generalized parodontitis of primary-I, I–II degree, chronic course of anorexia nervosa in the oral fluid there was a significant violation of lipid metabolism – increase in the content of palmitic fatty acid (C 16:0) and decrease in the content of linoleic fatty acid (C 18:2). Conclusions. The revealed features of the course of GP in patients with anorexia nervosa indicate the need for additional treatment and prophylactic measures in this group of patients. Disorders of the fatty acid spectrum of the oral fluid in these patients were necessitate the inclusion in the traditional scheme of treatment of GP aimed at correcting the processes of antioxidant protection, which increase the effectiveness of therapeutic and prophylactic effects. Keywords: generalized parodontitis, anorexia nervosa, fatty acids, oral fluid, oxidative-oxidant stress.
To plan the treatment of GPD in patients with anorexia nervosa, the format of a personal assessment of the level of compliance was verified. Materials and research methods. The research involved 58 patients with GPD, suffering from AN, restrictive form, and 62 patients with GPD without signs of anorexia at the age of 18-25 years. The control group was represented by 30 healthy people with normal weight and clinically intact periodontium. Clinical-radiological and medical-psychological methods were used. Results and its discussion. Low level of emotional (E), social (S), behavioral (B) and general (G) compliance with a frequency of 70-75, 61-65, 40-65 and 60-70 % respectively has been established in patients with GPD afiliated with AN, which may indicate the complexity of achieving sustained and long-term remission and the effectiveness of preventative measures for GPD. A high level of all components of compliance in patients with GPD afiliated with AN was identified in only 6, 10, 11-27.5 and 10-20 % of the surveyed patients, respectively. Among patients with GPD without signs of AN. The average level of all components of compliance (E, S, B, G) with frequency of 45-76, 46,6-73,3, 70-73,3 and 30-63.3 %, respectively, was prevalent. Conclusions: the low level of all components of compliance (E, S, B, G) in patients with GPD suffering from AN, indicates the potential complexity of promising treatment and leads to the involvement of related profile specialists; patients with AN can be attributed to the risk of satisfactory, sustainable, long-term and predictable outcome of treatment for GPD; taking into account the determination of the level of compliance in patients with GPD afiliated with AN is an important factor in ensuring the effectiveness of the comprehensive treatment and prevention process.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.