Antioxidant stress as an indicative marker of diagnosis and vector verification of treatment of generalized parodontitis with anorexia nervosa

Abstract

Purpose of the study. To study the balance of fatty acid spectrum of oral lipids as a marker of oxidant-antioxidant stress in patients with generalized parodontitis with anorexia nervosa. Materials and methods. The study metabolic disorders of fatty acids oral fluid was conducted in 28 patients with GP, primary-I, I–II degree, chronic course associated with anorexia nervosa, (average age 26 ± 3,8) – the main group (M). The comparison group (C) included 23 patients with GP, primary-I, I–II degree, chronic course with no eating disorders. The control group consisted of 25 healthy individuals of the same age category. Patients' oral fluid was used as the object of study. In the spectrum of fatty acids of lipids of the oral fluid, the 9 most informative fatty acids were identified: myristic C 14:0,pentodecane C 15:0, palmitic C 16:0, margarine C 17:0,stearic C 18:0, oleic C 18:1, linoleum C 18:2, linolen C 18:3, arachidone C 20:4. Quantification of the spectrum of lipid fatty acids was performed by the method of normalization of planes and determined the proportion of acids in percents. Results. The fatty acid content of the oral fluid of patients in the main group was significantly different from the control parameters. 12% in patients with anorexia nervosa significantly increased the amount of saturated fatty acids by increasing the content of palmitic acid (C 160) and reducing stearic acid (C 18:0) by 2 times compared with control.It was established that the sum of unsaturated fatty acids was reduced by 2 times due to polyunsaturated fatty acids, and this level was significantly reduced by 2 times in comparison with control group due to 3 times reduction of linoleum fatty acid (C 18:2), linolenic fatty acid (C 18:3) 2-fold and unreliable increase in arachidone fatty acid (C 20:4), in comparison with the control, which in our opinion, reflects disturbance of the oxidant-antioxidant balance and is a marker of stress as an indicator of endogenous intoxication in patients with GP and anorexia nervosa.In patients with generalized parodontitis of primary-I, I–II degree, chronic course of anorexia nervosa in the oral fluid there was a significant violation of lipid metabolism – increase in the content of palmitic fatty acid (C 16:0) and decrease in the content of linoleic fatty acid (C 18:2). Conclusions. The revealed features of the course of GP in patients with anorexia nervosa indicate the need for additional treatment and prophylactic measures in this group of patients. Disorders of the fatty acid spectrum of the oral fluid in these patients were necessitate the inclusion in the traditional scheme of treatment of GP aimed at correcting the processes of antioxidant protection, which increase the effectiveness of therapeutic and prophylactic effects. Keywords: generalized parodontitis, anorexia nervosa, fatty acids, oral fluid, oxidative-oxidant stress.

El Rol de los Trastornos de Conducta Alimentaria sobre la Periodontitis: Breve Revisión Sistemática de Estudios Observacionales

“…La anorexia nerviosa posee una etiología psiquiátrica, caracterizada por condiciones coexistentes con los rasgos de personalidad, genética, biología cerebral y hábitos culturales, donde esta distorsión mental genera una alteración sobre la imagen corporal que puede conllevar la resolución de medidas extremas como la restricción energética, comportamiento físico activo, ingesta de medicamentos (laxantes, diuréticos y supresores del apetito) y recurrencia del vomito autoinducido, cuyas implicancias psicosociales pueden llevar en última instancia a desenlaces suicidas durante la adolescencia y adultez temprana (Lo Russo et al, 2008;Lourenço et al, 2018;Pallier et al, 2019;Antonenko et al, 2020a;Boillot et al, 2020;Mitchell & Peterson, 2020). En este contexto, durante la adolescencia y adultez Escuela de Odontología, Facultad de Odontología, Universidad Andrés Bello, Concepción, Chile.…”

“…Received: 2022-10-20 Accepted: 2022-12-29 temprana el cuadro anoréxico de tipo restrictivo puede evolucionar en una anorexia nerviosa Compulsiva/purgativa, caracterizada por restricciones calóricas acompañadas de atracones o purgas (vómito autoinducido) producto del rechazo hacia la mantención de un peso corporal saludable en función de la edad y talla (Garrido-Martínez et al, 2019;Pallier et al, 2019;Antonenko et al, 2020a;Mitchell & Peterson, 2020).…”

“…En cuanto a la bulimia nerviosa, esta se caracteriza por presentarse en etapas vitales tardía en comparación con la anorexia nerviosa, siendo ambos TCA generalmente vinculados en forma simultánea (24 % a 31 %), donde la prevalencia de TCA en mujeres adultas reporta resultados variables dependiendo de las características propias de estos trastornos como los episodios de atracones recurrentes (ingesta alimentaria excesiva durante cortos periodos) relacionados a la ansiedad, depresión y/o soledad, cuya recurrencia promedio alcanza los dos episodios semanales (Lo Russo et al, 2008;Panico et al, 2018;Chiba et al, 2019;Wade, 2019;Antonenko et al, 2020a).…”