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Computational models and experimental results suggest that the proposed applicator may have potential for delivering conformal thermal therapy in the intact breast.

A new design methodology for radiofrequency circuits is presented that includes electromagnetic (EM) simulation of the inductors into the optimization flow. This is achieved by previously generating the Pareto-optimal front (POF) of the inductors using EM simulation. Inductors are selected from the Pareto front and their S-parameter matrix is included in the circuit netlist that is simulated using an RF simulator. Generating the EM-simulated POF of inductors is computationally expensive, but once generated, it can be used for any circuit design. The methodology is illustrated both for a single-objective and a multi-objective optimization of a Low Noise Amplifier.

Abstract-This study quantifies the detuning and impedance mismatch of antennas implanted inside the human body. Maximum frequency shifts caused by variations in the electrical properties of body tissues and different anatomical distributions were derived. The results are relevant to the design of implantable antennas. They indicate the bandwidth enhancement and initial tuning necessary for correct functioning. The study was carried out using electromagnetic modeling based on the finite-difference time-domain method and highresolution anatomical models. Four anatomical computer models of two adults and two children were used. The implanted antennas operated in the Medical Implant Communication Service band. The most important detuning and impedance mismatch was found for subcutaneous locations and in areas where a layer of fat tissue was present. The maximum frequency shift towards higher frequencies was 70 MHz. The frequency shift did not occur symmetrically around 403 MHz, but was shifted towards higher frequencies.

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