The review, based on modern literature data and the results of many years of research conducted by the authors, highlights the problem of comorbidity (multimorbidity) in children with bronchial asthma (BA). There is a grouping of concomitant diseases in children with asthma depending on the type of comorbidity (causal, complicated, unspecified, reverse). Based on epidemiological data, observational and cohort studies, systematic reviews and meta-analyses, information on the frequency of BA in children with various comorbid diseases and comorbid diseases in children with BA was summarized. Scientific, theoretical and practical significance of comorbidity in BA, diagnostic and treatment programs in pediatric patients suffering from BA and comorbid diseases are substantiated.
The most severe course of COVID-19 is observed in patients with vascular comorbidity (more than 3 cardiovascular diseases). At the same time, a large number of complications from various organs and systems are recorded in this group of patients, with acute stroke being one of the most severe. Stroke in patients with COVID-19 is characterized by a severe clinical course, with a high rate of deaths and poor rehabilitation prognosis in the early and late recovery period. The cohort combined retrospective-prospective study included 80 patients. All subjects were divided into groups: 1) patients with stroke and COVID-19; 2) stroke patients without COVID-19; 3) COVID-19 patients without stroke. All patients underwent complex clinical and laboratory monitoring, including general and biochemical blood tests, assessment of hemostasis and the level of pro-inflammatory cytokines, and MSCT of the brain and lungs. As a result of the study, it was found that patients with stroke and COVID-19 have a more severe course of the disease with a high incidence of multiple organ dysfunction syndrome (MODS) and deaths at the hospital stage.
Despite the modern advances of medicine, the incidence and death rate of COVID-19 remains quite high. The data about complications associated with the infection caused by SARS-CoV-2 are constantly updated. There is more and more information about complications from the nervous system, where stroke plays a leading role. The desire to more accurately understand the mechanisms of stroke development in patients with the novel coronavirus infection and the search for ways to improve the results of treatment of this pathology incurred the analysis of 289 cases of the new coronavirus infection in the specialized hospital of the City Clinical Hospital No. 15 named after O.M. Filatov (Moscow) for the period March-June 2020. All patients underwent the analysis of clinical, laboratory, and instrumental data. The features of the course of stroke against the background of COVID-19 and changes in indicators of clinical, laboratory and instrumental research methods are considered. The most common forms of extracerebral pathology in stroke in patients with COVID-19 are shown. English version of the article on pp. 569-576 is available at URL: https://panor.ru/articles/features-of-the-acute-stroke-run-associated-with-the-new-coronavirus-infection-covid-19/70262.html
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