Vulvar Paget's disease (VPD) is classified into primary and secondary types. Differentiation of these subsets in biopsy specimen is important for appropriate therapy. Expression profile of cytokeratin (CK) 7 and CK20, gross cystic disease fluid protein-15 and uroplakin III has been reported as a differentiation marker of primary and secondary VPD. To examine the role of p63 immunostaining in differential diagnosis between primary VPD and VPD secondary to urothelial carcinoma (VPD-UC), expression of p63 was examined in nine cases of VPD. Paget cells in seven cases of VPD without UC did not express p63. In two cases of VPD associated with UC, Paget cells and UC cells had identical CK expression profile. UC cells were positive for p63 in both cases. In one case, Paget cells were positive for p63 and examination of the resected specimen showed that VPD was secondary to UC. In another case, Paget cells were negative for p63 and this was diagnosed as primary VPD independent of UC. This indicates that p63 is absent in Paget cells in primary VPD and is therefore useful in differentiating primary VPD from VPD-UC.

Abstract-Techniques for the optimal design of permanent magnet motors considering rotation are investigated. The nonconforming mesh technique is used to take into account the rotation of rotor. It is shown that the technique is especially useful for the optimal design using the finite element method, because no modification of mesh is necessary during the rotation. The mesh at each angle of rotation can be obtained by only combining meshes of a rotor and a stator. By using the combined optimization technique of the experimental design method and the Rosenbrock's method, the number of FEM calculations can be fairly reduced. By applying the optimal design method, about 40% of volume of permanent magnet of IPM motor and about 15% of the torque ripple can be reduced.