Lung abnormalities are highly risky conditions in humans. The early diagnosis of lung abnormalities is essential to reduce the risk by enabling quick and efficient treatment. This research work aims to propose a Deep-Learning (DL) framework to examine lung pneumonia and the cancer. This work proposes two different DL practices to evaluate the considered problem: (i) The initial DL method, named a modified AlexNet (MAN), is implemented to classify chest X-Ray images into normal and pneumonia class. In the MAN, the classification is implemented using with Support Vector Machine (SVM), and its performance is compared against Softmax. Further, its performance is validated with other pre-trained DL techniques, such as AlexNet, VGG16, VGG19 and ResNet50. (ii) The second DL work implements a fusion of handcrafted and learned features in the MAN to improve the classification accuracy during lung cancer assessment. This work employs serial fusion and Principal Component Analysis (PCA) based features selection to enhance the feature vector. The performance of this DL structure is tested by the benchmark lung cancer CT images of LIDC-IDRI and superior classification accuracy of >97.27% is achieved.

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Histogram based multilevel thresholding approach is proposed using Brownian distribution (BD) guided firefly algorithm (FA). A bounded search technique is also presented to improve the optimization accuracy with lesser search iterations. Otsu's betweenclass variance function is maximized to obtain optimal threshold level for gray scale images. The performances of the proposed algorithm are demonstrated by considering twelve benchmark images and are compared with the existing FA algorithms such as Lévy flight (LF) guided FA and random operator guided FA. The performance assessment comparison between the proposed and existing firefly algorithms is carried using prevailing parameters such as objective function, standard deviation, peak-to-signal ratio (PSNR), structural similarity (SSIM) index, and search time of CPU. The results show that BD guided FA provides better objective function, PSNR, and SSIM, whereas LF based FA provides faster convergence with relatively lower CPU time.

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The work proposes a computer-based diagnosis method (CBDM) to delineate and assess the corpus callosum (CC) segment from the 2-dimensional (2D) brain magnetic resonance images (MRI). The proposed CBDM consists of two parts: (1) preprocessing and (2) postprocessing sections. The preprocessing tools have a multithreshold technique with the chaotic cuckoo search (CCS) algorithm and a preferred threshold procedure. The postprocessing employs a delineation process for extracting the CC section. The proposed CBDM finally extracts the vital CC parameters, such as total brain area (TBA) and CC area (CCA) to classify the considered 2D MRI slices into the control and autism spectrum disorder (ASD) groups. This attempt considers the benchmark brain MRI database which includes ABIDE and MIDAS for the experimental investigation. The results obtained with ABIDE dataset are further confirmed against the fuzzy C -means driven level set (FCM + LS) and multiphase level set (MLS) technique and the proposed CBDM with Shannon entropy along with active contour (SE + AC) presented improved result in comparison to the existing methodologies. Further, the performance of CBDM is confirmed on MIDAS and clinical dataset. The experimental outcomes approve that the proposed CBDM extracts the CC section from the 2D MR brain images that have higher accuracy compared to alternative techniques.

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