Abstract. We report the results of the experimental study of optical immersion clearing of laboratory animals skin in vivo with preliminary laser ablation of epidermis. It is shown that the ablation of the skin surface leads to the local edema that reduces the optical detection depth immediately after the impact. However, the water evaporation from the damaged epidermis causes the optical clearing of skin, comparable with that caused by polyethylene glycol in intact skin. It is shown that the preliminary ablation of the skin surface before the application of immersion agent does not lead to significant increase of the optical detection depth as compared to the sole effect of ablation or immersion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.