The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated.

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Abstract:Primary rhabdomyosarcoma (RMS) of breast and RMS, metastatic to breast are rare entities with limited case reports in literature. Here, we report a case of primary rhabdomyosarcoma of breast in an adolescent girl which was metastatic at presentation. She presented with progressively increasing lump in right breast with difficulty in breathing. Histopathology was suggestive of solid variant of alveolar type/embryonal carcinoma (undifferentiated type). Immunohistochemical reports were positive for muscle markers Vimentin and Myf-4, making definitive diagnosis of RMS. Patient had fast progression of disease and died after first cycle of chemotherapy.

Background: Regorafenib is an oral diphenyl urea multikinase inhibitor which is anti-angiogenic, and has shown promising anti-tumor activity in Metastatic Colorectal Cancer (mCRC). Reports have shown that response to regorafenib is more favourable in patients with KDR gene mutation. This study correlates KDR gene mutation as an ideal predictive biomarker to regorafenib (Tyrosine Kinase Inhibitor) attempts to correlate response in metastatic colorectal cancer (MCRC).

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