Background: Regorafenib is an oral diphenyl urea multikinase inhibitor which is anti-angiogenic, and has shown promising anti-tumor activity in Metastatic Colorectal Cancer (mCRC). Reports have shown that response to regorafenib is more favourable in patients with KDR gene mutation. This study correlates KDR gene mutation as an ideal predictive biomarker to regorafenib (Tyrosine Kinase Inhibitor) attempts to correlate response in metastatic colorectal cancer (MCRC).
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