Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.
We analyzed the information of the state ofperitoneal dialysis in Ukraine for the period 2009–2013. The authors are grateful to all the main coordinators of the regional registries who had sent the relevant information to the SI «Institute of Nephrology NAMS of Ukraine», and contributed to the formation of the National Register.
Abstract. The present study aimed to evaluate the dynamics of the incidence of acute cystitis in Ukrainian children in the regional aspect.
Methods. The primary documentation is presented by the data of state and branch statistical reports of the institutions of the Ministry of Health of Ukraine for 2013-2017. There are age periods - children under 14 and 15 - 17 years. The indicators were analyzed for Ukraine as a whole, five of its regions, and the regions that make them up.
Results. At stabilization of morbidity of children till 14 years which specific weight reaches 70%, annual growth of sick teenagers (on 28,0% from 2013 to 2017) is noted.
Conclusionі. Administrative areas have been identified that require increased attention from health authorities and clinicians to develop appropriate measures.
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