Plasma samples from 28 renal allograft recipients were studied for the presence of alloantibodies blocking MLC response. MLC blocking antibodies were found in plasma samples obtained from 19 recipients, six with rejected allograft and 13 with long-term surviving transplant. In many instances, these antibodies were found in the absence of detectable lymphocytotoxic antibodies. The MLC blocking activity resides in IgG fractions of plasma sarnples and was decreased only after absorption with lymphocytes, no effect on blocking was observed by absorption with platelets and fibroblasts.
A first cousin marriage family with three children was studied. One sibling (AW) was homo‐zygous for W32.WlO. When used as stimulator in one way MLC, AW elicited a very low response in family members possessing this haplotype. Serologically identical sibling and father combination showed bidirectional non‐stimulation in one way MLC. Therefore, AW is assumed to be homozygous not only for SD antigens, but also for LD determinants which we call LD WlOa. Among the 43 unrelated individuals tested with AW, an association be‐tween LD WlOa and W10 antigen of the second HL‐A locus was observed. Of 12 W10 positive individuals tested, five carry this allele as compared to one out of 31 W10 negative individuals. The data suggest a strong linkage disequilibrium between the FOUR locus de‐terminant W10 and LD determinant LD WlOa.
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