C O M P O U N D S OF S e m p e r v i v u m L. A. G u m e n y u k , V. S. B a t y u k , a n d N. N. D y k h a n o v r u t h e n i c u m UDC 547.972The phenolic compounds of the epigeal p a r t of the plant Sempervivum ruthenicum consist of d e r i v atives of flavone, enol carboxylic acids, hydroxycoumarins, and tanning substances of the pyrogallol and catechol groups [1, 2].To isolate the individual substances, extracts from Sempervivum ruthenicum after the elimination of the solvent, were exhaustively extracted with chloroform and then with ethyl acetate.When the chloroformic e x t r a c t s were chromatographed on a column of alumina (Brockmann activity grade II), a substance C9H60 z with mp 65-67°C, identified as coumarin, was isolated. The ethyl acetate fraction gave a mixture of flavonoids (0.6% of the weight of the raw material) which was chromatographed on a column of Kapron. By using ethanol of various concentrations as eluents, we isolated three substances: astragalin, C~.IH20Oll , m p 174-176°C, [a]~--56.0°; kaempferol, C15H1006, mp 330-331°C; and qucrcetin, Ct5Hi00~, mp 310-312°C.The aqueous phase remaining after the extraction with ethyl acetate was concentrated in vacuum to small volume and was likewise chromatographed on a column of Kapron. When the column was eluted with 40% ethanol, a substance C2yH30017 with mp 190-191°C (from ethanol), [o~]~--32.0 °, was obtained.Both acid hydrolysis (5% H2SO 4) and enzymatic cleavage of the glycoside with a preparation from Aspergillus oryzae gave quercetin (yield 48%), D-glucose, and L -r h a m n o s e .
Abstractp‐Hydroxybenzoesäure (I) wird mittels Acetanhydrid in die Acetoxy‐benzoesäure (II) übergeführt, Umsetzung mit SOCl2 gibt das Säurechlorid (III), welches mit Benzylalkohol zum Ester (IV) reagiert.
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