Flavonoid compounds from the flowers of Sempervivum ruthenicum

Gumenyuk, L. A.; Dykhanov, N. N.; Batyuk, V. S.

doi:10.1007/bf00563761

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“…The remainder of phenolic compounds have yet to be identified and quantified. Previous studies show the presence of phenolic acids both in Sempervivum ruthenicum Koch [10], as well as in other species of the genus [4][5][6][7][8][9]. These findings suggest that Sempervivum species represent a good source of natural Table 1 POLYPHENOLIC ACIDS QUANTIFIED BY HPLC-DAD FROM A SEMPERVIVUM RUTHENICUM KOCH HYDROETHANOLIC EXTRACT polyphenols.…”

Section: Hplc Analysismentioning

confidence: 79%

“…Members of the Sempervivum family are well known in folk medicine, being used in a variety of disorders such as bacterial otitis, burn wounds and peptic ulcers [4][5][6]. Most sources mention the usage of either fresh leaf juice or decoctions, to obtain a pharmacological effect, however, no phytochemical analysis of this plant has been published apart from those made by Gomeyuk et al [7,8] that highlights the presence of polyphenolic compounds and flavonoids [9].…”

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confidence: 99%

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Phytochemical Profile and Total Antioxidant Capacity of Sempervivum ruthenicum Koch Hydroethanolic Extract

Mihai¹,

Dumitrescu²,

Raducanu³

et al. 2019

Rev. Chim.

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The scope of this work is a phytochemical analysis and antioxidant activity assay of a Sempervivum ruthenicum Koch hydroethanolic extract. The hydroethanolic extract was prepared from the dried leaves of the plant by maceration in a water and methanol mixture (50:50 v/v). The total phenolic content of the extract was calculated to be 3.0501�0.0272 mg/mL and the total flavonoid content was determined in a concentration of 3.113�0.0394 mg/mL. The HPLC-DAD analysis revealed phenolic acids and flavonoids, which were quantified. The most prevalent phenolic acids in the extracts were gallic and ellagic acids, with concentrations of 1.2443�0.0475 mg/mL, respectively 0.6339�0.0026 mg/mL. The heteroside astragalin was present in high concentration of 1.1934�0.0754 mg/mL. The DPPH free radical scavenging assay revealed the EC50 value of the extract to be 2.5788�0.003 mg/mL. These results suggest a good scavenging ability of the extract, which is due to the abundance of polyphenolic compounds. The antioxidant activity of the extract demonstrates a high scavenging ability at low doses. Sempervivum ruthenicum Koch shows a promising phytochemical profile that suggests it�s use in pathological conditions that involve high oxidative stress.

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