Chronic polypous rhinosinusitis (CPR) is an immune disease based of the chronic inflammation and remodelling of the nasal mucosa and paranasal sinuses. The objective of the work is to study morphological changes of the polypous tissue removed from the nasal cavity and paranasal sinuses to determine the structural features characteristic for CPR pathogenesis. The authors examined 84 persons with CPR. The first group included 44 patients in which CPR was not combined with bronchial asthma (BA). The second group comprised 40 patients with CPR with BA. All the patients underwent endonasal polypectomy. The histological material was processed according to the standard method to obtain histological preparations. In cases of CPR combined with BA the basal membrane thickening was observed, as well as the expressed oedema of the mucous membrane layer and the mucous gland hyperplasia with cysts generation against the background of the expressed infiltration with eosinophil granulocytes and plasma cells. Without BA, the basal membrane had no clear structure, the cellular infiltration was presented mainly by lymphocytes and neutrophils, and, to a lesser extent, by eosinophils granulocytes and plasma cells.
The research is conducted for the purpose of determination of the morphological changes in maxillary sinuses mucous membrane during cyst formation diagnostics depending on clinical progression features. 35 patients with of cysts in maxillary sinuses have been examined. All the patients have undergone the FESS by standard method. The material excised in the process of the operation was registered by means of standard technique, histologic specimen were stained with hematoxylin and eosin, azur blue dye, picro-fuchsin according to Van-Gizon method, alcian blue. We have established that the morphological pattern of surgical material feature with inflammatory changes of both chronic and acute nature. Detection of specific process signs (Wegener’s granulomatosis, aspergillomycosis) based on the results of morphological research facilitates the order of specific treatment methods and provides better results in treatment of maxillary sinuses cysts.
The aim of the research is to determine the main clinical, morphological and immunohistochemical manifestations of hypertrophy and chronic tonsillitis in different age groups of children who are frequently ill. Materials and methods. The objects of the research were the medical histories and surgical materials after tonsillotomy (patients under the age of 6 inclusive) and tonsillectomy (patients from 7 years old) of 48 children’s tonsils. 4 age groups of children were identified. Qualitative assessment of epithelial cells, subepithelial layer of connective tissue, contents of lacunae, follicular and interfollicular lymphoid tissue, stromal component of palatine tonsils as well as distribution of T- and B-lymphocytes in palatine tonsils’ tissue was performed. Morphological changes in the lymphoid tissue of palatine tonsils in children of patients under the age of 6 indicate the preservation of immune activity during interaction with most foreign invader. The most pronounced decrease in the volume of lymphoid tissue because of fibrosis is observed in children between the ages 13 – 18 years old.
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