The present-day aspects of chronic polypous rhinosinusitis immunopathogenesis

Abstract

Chronic polypous rhinosinusitis (CPR) is an immune disease based of the chronic inflammation and remodelling of the nasal mucosa and paranasal sinuses. The objective of the work is to study morphological changes of the polypous tissue removed from the nasal cavity and paranasal sinuses to determine the structural features characteristic for CPR pathogenesis. The authors examined 84 persons with CPR. The first group included 44 patients in which CPR was not combined with bronchial asthma (BA). The second group comprised 40 patients with CPR with BA. All the patients underwent endonasal polypectomy. The histological material was processed according to the standard method to obtain histological preparations. In cases of CPR combined with BA the basal membrane thickening was observed, as well as the expressed oedema of the mucous membrane layer and the mucous gland hyperplasia with cysts generation against the background of the expressed infiltration with eosinophil granulocytes and plasma cells. Without BA, the basal membrane had no clear structure, the cellular infiltration was presented mainly by lymphocytes and neutrophils, and, to a lesser extent, by eosinophils granulocytes and plasma cells.