Alteration in lipid peroxidation products such as lipid peroxides, lipid hydroperoxides were studied in different regions of CNS of ageing rats (13, 26, 52, 78 and 104 weeks). The levels of lipid peroxide and lipid hydroperoxide were increased in various regions of brain and spinal cord. However, the activity of superoxide dismutase was decreased in cerebrum, hypothalamus, hippocampus, cerebellum, brain stem and spinal cord. The present communication demonstrates that the different parts of CNS at 13 and 26 weeks of age have lipid peroxidation products different from that of 104-week-old rats.
The hypolipidaemic action of picroliv, a standarized preparaton from Picrorhb kurrooa, has been studied in normal as well as in triton-and cholesterol-fed rats. Serum lipids were found to be lowered by picroliv (25 mglkg b.w.) in triton WR-1339-induced hyperlipaemia. Chronic feeding of this drug (6 mglkg b.w.) in normal rats and in animals simultaneously treated with cholesterol (25 mglkg h.w.) for 30 days caused lowering in the lipid and protein levels constituting &lipoproteins followed by an increase in high density lipoprotein cholesterol in experimental animals. Picroliv alters lipolytic activities in plasma, liver, heart an adipose tissues and stimulated receptor mediated catabolism of low density lipoprotein. The lipid lowering action of the natural product is mediated through inhibition of cholesterol biosynthesis in liver, increased faecal bile acid excretion and enhanced plasma lecithin : cholesterol acyltransferase activity.
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