Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions

Chander, Ramesh; Kapoor, N. K.; Dhawan, B. N.

doi:10.1016/0006-2952(92)90054-m

Cited by 116 publications

(67 citation statements)

References 14 publications

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“…In the present study, compounds with small molecular mass picroside I (MW 492 kDa) and picroside II (MW 512 kDa) were identified in the ethanol extracts of P. scrophulariiflora. The significant antioxidant properties of picroside I and II have been demonstrated in both in vitro and in vivo studies (Chander et al 1992, Gao & Zhou 2005, Li et al 2007b. Although we cannot exclude the possible effects of unidentified components in EPS, picroside I and II appear to play a major role in the in vivo anti-inflammation activity.…”

Section: Discussionmentioning

confidence: 77%

“…Picrorhiza is almost insoluble in water but soluble in organic solvents (Luper 1998, Smit et al 2000. Although many components of Picrorhiza have not been identified, evidence has shown that organic solvent extracts of Picrorhiza, such as picroside I, II, and kutkoside, have antioxidant activity similar to that of superoxide dismutase (Chander et al 1992). Therefore, we hypothesized that the ethanol extract of PS (EPS) would decrease inflammation in the diabetic kidney and thus slow down the development of the early structural and functional abnormalities which lead to diabetic nephropathy.…”

Section: Introductionmentioning

confidence: 99%

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Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

He¹,

Liang²,

Hou³

et al. 2008

Journal of Endocrinology

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There is evidence that inflammatory processes are involved in the development and/or progression of diabetic nephropathy. However, effective treatment for inflammation in the kidneys of diabetic is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the ethanol extract of PS (EPS) may reduce inflammation in patients with diabetic kidneys. Streptozotocin-induced diabetic rats were randomly assigned to two groups treated with a gavage of either EPS or vehicle. A group of non-diabetic control rats was treated concurrently. Compared with vehicle-treated diabetic rats, EPS-treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of chemokine (C-C motif) ligand 2 (CCL2) and TGFB1. This was associated with attenuation of the structural and functional abnormalities of early diabetic nephropathy, such as glomerular hypertrophy, mesangial expansion, and albuminuria. Administration of EPS significantly reduced NADPH oxidase-dependent superoxide generation and decreased expression of malondialdehyde and advanced oxidation protein products in diabetic kidney. These data suggest that EPS might improve diabetic nephropathy, probably through inhibition of redox-sensitive inflammation.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

He¹,

Liang²,

Hou³

et al. 2008

Journal of Endocrinology

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“…Several phenolic and terpenic compounds have been reported to be good antioxidants in some in vitro antioxidative assay models (Chander et al, 1992;Harborne, 1994;Hostettmann and Marston, 1995;Jimenez and Riguera, 1994;Zhao et al, 2005). However, there is no report concerning the ROS-catalyzed oxidation of isolated compounds in living human cells.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, it was displayed that vaniloyl ajugol showed moderate activity, because of its phenolic system, although few reports appeared in the literature on the antioxidant activity of iridoid glycosides (Chander et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

Screening for Free Radical Scavenging and Cell Aggregation Inhibitory Activities by Secondary Metabolites from Turkish Verbascum species

Tatlı

Takamatsu

Khan

et al. 2007

Zeitschrift Für Naturforschung C

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Free radical scavenging and cell aggregation inhibitory activities of 36 secondary metabolites isolated from the methanolic extracts of Verbascum cilicicum Boiss., V. lasianthum Boiss. ex Bentham, V. pterocalycinum var. mutense Hub.-Mor., and V. salviifolium Boiss. (Scrophulariaceae) were investigated. The isolated compounds, 6-O-vaniloyl ajugol (1), ilwensisaponin A (2), ilwensisaponin C (3), verbascoside (4), -hydroxyacteoside (5), martynoside (6), poliumoside (7), forsythoside B (8), angoroside A (9), dehydrodiconiferyl alcohol-9-O--d-glucopyranoside (10), dehydrodiconiferyl alcohol-9Ј-O--d-glucopyranoside (11), apigenin 7-O--glucopyranoside (12), luteolin 7-O--glucopyranoside (13), luteolin 3Ј-O--glucopyranoside (14) and chrysoeriol 7-O--glucopyranoside (15), exhibited a dose-dependent inhibition of bioautographic and spectrophotometric DPPH activities. Verbascoside (4) was the most active (IC 50 4.0 μg/ml) comparing it to vitamin C (IC 50 4.4 μg/ml) to inhibit phorbol 12-myristate 13-acetate (PMA)-induced peroxide-catalyzed oxidation of 2Ј,7Ј-dichlorofluorescein (DCFH) by reactive oxygen species (ROS) within human promyelocytic HL-60 cells. Ilwensisaponin A (2) (MIC 6.9 μg/ml) showed moderate in vitro activity on lymphocyte-associated antigen-1 (LFA-1)/intercellular adhesion molecule-1 (ICAM-1)-mediated aggregation using the HL-60 cell line [positive control was cytochalasin B (MIC 2.3 μg/ml)]. None of the other compounds showed free radical scavenging and cell aggregation inhibitory activities.

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“…Picroliv is an alcoholic extract from the root of Picrorhiza kurroa that contains the iridoid glycosides kutkoside and picroside. In the rat these glycosides act as antioxidants 51 and ameliorate the hepatotoxic effects of carbon tetrachloride, 52 thioacetamide, galactosamine, 53 and paracetamol. 54 Despite their wide oral usage in India, no reliable data for human liver disease exist.…”

Section: Studies Of Defined Formulations Of Herbal Medicinesmentioning

confidence: 99%

Herbal products for liver diseases: A therapeutic challenge for the new millennium

et al. 1999

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Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions

Cited by 116 publications

References 14 publications

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

Screening for Free Radical Scavenging and Cell Aggregation Inhibitory Activities by Secondary Metabolites from Turkish Verbascum species

Herbal products for liver diseases: A therapeutic challenge for the new millennium

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