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This paper simulates and predicts the laminar flow inside the 3D aneurysm geometry, since the hemodynamic situation in the blood vessels is difficult to determine and visualize using standard imaging techniques, for example, magnetic resonance imaging (MRI). Three different types of Lattice Boltzmann (LB) models are computed, namely, single relaxation time (SRT), multiple relaxation time (MRT), and regularized BGK models. The results obtained using these different versions of the LB-based code will then be validated with ANSYS FLUENT, a commercially available finite volume- (FV-) based CFD solver. The simulated flow profiles that include velocity, pressure, and wall shear stress (WSS) are then compared between the two solvers. The predicted outcomes show that all the LB models are comparable and in good agreement with the FVM solver for complex blood flow simulation. The findings also show minor differences in their WSS profiles. The performance of the parallel implementation for each solver is also included and discussed in this paper. In terms of parallelization, it was shown that LBM-based code performed better in terms of the computation time required.

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Genus Calophyllum is well-known for its phenolic constituents, especially coumarins, which have shown to have a wide range of significant biological activities. In this study, four known phenolic constituents and two triterpenoids have been isolated from the stem bark of Calophyllum lanigerum. The compounds were two pyranochromanone acids are known as caloteysmannic acid (1), isocalolongic acid (2), a simple dihydroxyxanthone, namely euxanthone (3), one coumarin named calanone (4), and two common triterpenoids, friedelin (5), and stigmasterol (6). Chromanone acids were reported for the first time in this Calophyllum species. Cytotoxic evaluations were carried out on n-hexane extract (87.14 ± 2.04 µg/mL; 81.46 ± 2.42 µg/mL) followed by the chromanone acids (1 [79.96 ± 2.39 µM; 83.41 ± 3.39 µM] & 2 [57.88 ± 2.34; 53.04 ± 3.18 µM]) against two cancerous cell lines, MDA-MB-231 and MG-63 cell lines, respectively. The results showed that all tested samples exhibited moderate cytotoxicity.

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The key feature of the bi-leaflet valve is the geometry of the two leaflets, which can be crucial in determining the flow field. In this paper, observations were made on the flow pattern of the blood through the use of bi-leaflet type mechanical prosthetic valve (MHV). Finite volume method (FVM) analysis was conducted using fluidstructure interaction (FSI) method that solved on a dynamic mesh. In terms of the validation, particle image velocimetry (PIV) was used to verify the findings obtained from FVM analysis. The results of velocity and vorticity were the main parameters to be compared. Based on the findings, the results computed for the leaflets motion and the flow field using FVM was found to be in agreement with PIV experimental data. The pressure obtained for the simulation is in the range of 10,666-16,000 Pa, which is an ideal and healthy blood pressure level of human. The vorticity was observed to be formed behind the valve with DVI value of 1.275 (simulation) and 1.457 (experiment), lower than the expected range for a normal DVI in mitral valve. The maximum shear stress achieved (22.5481 Pa) is in the range of platelets activation, which could lead to thrombus formation. The maximum Von Mises stress was found to be at the hinge region of the bi-leaflet valve. These results will serve as a basis for valve design to improve the hemodynamic properties of the heart valve.

Abstract. In this work, an artificial heart valve is designed for use in real heart with further consideration on the effect of thrombosis, vorticity, and stress. The design of artificial heart valve model is constructed by Computer-aided design (CAD) modelling and simulated using Computational fluid dynamic (CFD) software. The effect of blood flow pattern, velocity and vorticity of the artificial heart valve design has been analysed in this research work. Based on the results, the artificial heart valve design shows that it has a Doppler velocity index that is less than the allowable standards for the left heart with values of more than 0.30 and less than 2.2. These values are safe to be used as replacement of the human heart valve.

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