Nowadays, many of the Agile based project development teams are distributed geographically across the globe. The teams are divided into onshore and offshore that work together to achieve on a common target. The teams in turn work in small iterations to minimize the effect of change in software requirements and at the same time developing regular communication between them. However different factors such as physical distance and lack of proper communication between the onshore and offshore teams become a hurdle between them leading to misunderstandings about software requirements. Though there are many advanced way of communication like video conferencing, voice chatting is available, it certainly has several disadvantages in getting the task completed. This paper gives an insight about these challenges faced in many of the software industries and it would allow different stakeholders within agile based onshore /offshore setting to better understand these challenges in eliciting their requirements.
Formerly with more augmented disabilities, Medical devices have become decisive device in many circumstances. As these are more perilous, the manufacturer should endow with an ideal medical device in aspects of safety & quality. To produce a homogeneous device globally, there should be some standards to be followed within an explicit country and standard throughout the globe, complying with the quality. In milieu of this resemblance of device globally, International Organization for Standard (ISO) has issued a standard, ISO 13485. This article is made to furnish the details about ISO 13485 and the Quality management system followed by United States manufacturer’s to market their devices within the country, i.e., 21 CFR Part 820.
: Japanese encephalitis virus (JEV) is an arthropod-borne flavivirus belongs to the Flaviviridae family affecting millions of peoples worldwide.There is no specific drug approved for the treatment of this infection and also available vaccines are not effective against all the clinical isolates. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more effective anti-JEV agents. Abscisic acid is a naturally occurring phytohormone released particularly in stress condition which controls leaf abscission. Recent studies have shown that the abscisic acid has the potential to inhibit virus by inhibiting protein disulfide isomerase enzyme which is important for the formation of viral proteins. Apart from this, abscisic acid could also reduce the neuroinflammation (a major hallmark of JEV infection) through stimulation of PPAR gamma. Thus, abscisic acid thereof could have the potential to develop as an anti-JEV agent.
Abstract: Agile Software Development Approach is the buzzword for the Organizations working with Traditional Software Development Approach. Scrum is one of the most vital frameworks used when working towards Agile Software Development projects. Material Management is one of the salient processes of the Supply Chain Management in transforming inputs into outputs. Extreme Programming is more technical in nature and Scrum is a People focused Management approach. This scrum framework is customizable according to the project teams and it is adopted widely to effectively manage software projects. Scrum framework fits into the groove for delivering quality product at a faster pace with minimal continuous feature delivery at frequent intervals. The minimal Marketable feature is delivered at the end of each Sprint. A Sprint is an iterative activity which ends up at regular intervals. But, the way of customizing the process and giving a minimal feature delivery at the end of each Sprint in the projects act as a major challenge. Other challenges resulted in the team collaboration and the involvement of the team members in the project and in integrating the minimal marketable feature.Syncing with the product owner and the other stake holders, and participation in the sprint planning were some of the issues that the team faced. The success of the entire team in implementing the Agile Software Development approach in the Enterprise Resource Planning Material Management Section is discussed.
Background: To overcome one of the resistance mechanisms of Isoniazid (INH), there is a need of antitubercular agent that can inhibit InhA enzyme by circumvents the formation of INH-NAD+ adduct. Objective: The objective of the study is the development of novel antitubercular agents that targets Mycobacterium tuberculosis InhA (Enoyl Acyl Carrier Protein Reductase). Methods: A small molecule chemical library was used for identification of the novel InhA inhibitors using primary screening and molecular docking studies followed by scaffold hopping approach. The designed molecules, 2-(2-(hydroxymethyl)-1H- benzo[d] imidazole-1-yl)- N- substituted acetamides were synthesized by reacting (1H- benzo[d]imidazole -2-yl)methanol with appropriate 2-chloro-N-substituted acetamides / dialkylamino carbonyl chlorides respectively in good yields (42-65%). The antitubercular activity of synthesized compounds was determined by Microplate Alamar Blue Assay (MABA) against Mycobacterium tuberculosis H37Rv strain. The selected compounds were screened for cytotoxicity on normal cell lines. Results: The antitubercular activity data revealed that the 4-chlorophenyl substituted derivative (3b) showed good MIC value at 6.25 µg/mL and, dimethylacetamide substituted derivative (3i) showed MIC at 25 µg/mL among the tested compounds. The substitution of dimethyl acetamide (3i) group on 1st position of benzimidazole has good antitubercular activity (25µg/mL) in comparison to the diethyl acetamide group (3j, 100µg/mL). Conclusion: The antitubercular activity data indicated that the tested compounds exhibited well to moderate inhibition of the H37Rv strains. The compounds (3b) with electronegative substitution on the phenyl moiety exhibited better antitubercular activity than that of the other substitutions. The active compounds have displayed good safety profile on normal cell lines.
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