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Rats given an initial infection with Angiostrongylus cantonensis had moderately elevated phospholipase B activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. In the brain, the values were elevated at 15 through 35 days. These periods of increased activity in the lungs and brain coincided with the migration patterns of the third-stage larvae and the adult worms in this host. The elevated enzyme levels also were correlated with increased numbers of eosinophils in the bone marrow at 8 and 15 days and again at 36, 43, and 49 days after infection. Similarly infected rats exhibited leukocytosis at 1 through 10 weeks of observation after challenge, and striking eosinophilia at 1, 7, 8, and 9 weeks. Rats reinfected after being blended, the snail tissue was digested in a 1% pepsin-1% HCl solution for 1 h at 37"C; the mixture was lightly centrifuged, and the sediment was resuspended in a gelatin-broth medium. After adjust-13 on August 5, 2020 by guest http://iai.asm.org/ Downloaded from

No abstract