Changements de la microcirculation dans la zone de restauration des défauts osseux des mâchoires à l'aide d'une matrice fibreuse polymère Introduction. L'un des domaines les plus spécifiques de la stomatologie pratique est l'utilisation de diverses structures de matrice biologique servant comme une épine dorsale aux cellules ostéogéniques et de cadre aux composants vasculaires assurant la formation progressive d'un nouveau tissu osseux dans la zone de défaut formée par l'énucléation résultante. Objectif. Établir l'efficacité de l'utilisation de la matrice fibreuse et de la membrane polymère dans le processus de restauration des défauts de la structure osseuse après la procédure d'énucléation sur la mâchoire inférieure et analyser les résultats avec ceux enregistrés lors de la réalisation de défauts osseux avec une éponge de collagène.
Background:The major challenge in tissue engineering is to optimize cell isolation, multiplication and differentiation, as well as to construct the matrices or delivery systems thereby promoting the maintenance and coordination of three-dimensional tissue regeneration. One of the important criteria that should be considered when constructing the matrix is its ability to form an optimal scaffold for the transplantation of the cell substrates.
Aim of the Study:To experimentally assess the nature of the development of the collagen scaffold during all the periods of subcutaneous implantation of the biopolymer fibrous matrix.
Materials and Methods:The study included 20 laboratory animals (rabbits) divided into 2 groups: 10 animals of Group I underwent surgery involving the creation of a subcutaneous pocket and suturing; 10 animals of Group II underwent subcutaneous implantation of the biopolymer matrix into the back area between the shoulder blades. Nine segments were used for the study, namely 1 centrally located segment, 4 segments of the paracentral zone, 4 segments of the peripheral zone. Statistical analysis of the results was conducted using software programs Microsoft Excel and Statistica 5.5 (Multiple Regression) by means of the methods of variation statistics, correlation.
Results:The results obtained indicated the absence of both acute and chronic reactive inflammatory infiltration, as well as both acute and chronic foreign-body response to the implant at the implantation site.
Conclusions:The fibrous matrix constructed by us creates a kind of the bridge for tissue ingrowth and the formation of a three-dimensional collagen matrix.
BackgroundBiopolymers are currently attracting increased attention in medicine and bioengineering. In tissue engineering, the materials for creating bioimplants must meet the following requirements: they must provide tissue engineered and microengineered constructs with the characteristics of living tissues, namely the ability to self-repair, as well as to change the structure and properties in response to the environmental factors [1]. The major challenge in tissue engineering is to optimize cell isolation, multiplication
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