Relevance: Male breast cancer (BC) has always been behind female BC in detection, treatment, and surveillance. Lower BC frequency in men
limits the usefulness of screening. However, BC incidence in men is growing.
This paper demonstrates the results of surgical treatment and typical changes in clinical and morphological manifestations of male breast
cancer under chemotherapy and surgery.
Methods: The article describes a clinical case of a male patient diagnosed with “Cancer in the right breast St III (T4NxM0), edematousinfiltrative form with an intraductal component, upper outer localization. Immunohistochemically luminal subtype B without Her2neu expression”;
the condition – after six neoadjuvant chemotherapy courses.
Results: Ultrasonography of the mammary glands conducted after six preoperative courses of chemotherapy showed a hypoechoic formation,
centralized, with fuzzy, uneven contours, 52.5×48.2×46.1 mm in size, V=60.98 cm3
. Compared to March 2022 (the presence of a formation in
the right breast craniolateral quadrant, with precise uneven contours, 9.0 cm in size, with infiltrating growth), the tumor formation decreased to
US BI-RADS R6, L2. The multidisciplinary council prescribed surgery to the extent of radical mastectomy by Madden on the right and simple
mastectomy on the left. The surgery was performed in August 2022. According to a postoperative histological conclusion, the therapeutic pathomorphism was index RCB-2.233, class RCB-II.
Conclusion: This article shares the results of systemic and surgical treatment of a man with breast cancer. Considering the clinical picture and
anamnesis, literature data, and the clinical protocol, the multidisciplinary group recommended radiation therapy with adjuvant endocrine therapy
with tamoxifen for an initial period of five years.
Relevance: Cancer during pregnancy is uncommon and found in 1/1000 pregnant women. An increasing number of women worldwide
plan childbearing at 30 years when the risk of malignant diseases increases. During pregnancy, cancers inherent with the reproductive
period in women are more likely. These cancers include breast cancer and cervix cancer. This article reviews the principles of treating
pregnant women with these cancers.
The study aimed to systematize relevant literature reviews for the past decade to efficiently choose diagnostic and treatment tactics for
pregnant women with breast cancer and cervix cancer without harming the fetus and gravid.
Methods: We analyzed the literature sources from different authors on the frequency of cancer of such localizations as breast cancer
and cervical cancer associated with pregnancy in patients of reproductive age. When selecting literary sources, attention was paid to the
history of the disease, complaints, features of diagnostic methods, and the choice of optimal treatment methods. The analysis was based on
comparative data from the studied literary sources for the past ten years.
Results: The value and the adequacy of different diagnostic methods of research that have no threat to gravid and fetus and are recommended for pregnant patients were established. Considering a patient’s condition, gestation, and stage of the disease, the best treatment
options for those cancer types were identified. Possibilities were studied on preserving patients’ fertility after treatment of these cancers.
Conclusion: Malignant tumors of the reproductive system alternating with pregnancy are statistically rare. However, medical oncologists have to solve the problem of the diagnosis and treatment of pregnant patients. The choice of the diagnostic methods and the type of
treatment must be individual. Having appropriate examinations and the staging done, Multidisciplinary Tumor Board approves the patient
management plan. Practitioners face the problematic issue of choosing optimal diagnostic and treatment measures, and this situation requires further investigations and methodological developments in pregnancy management complicated with oncological diseases
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