In 2400 consecutive patients at 8 clinics in 5 countries, nickel hypersensitivity was found in 176 cases (7.3%), 19 male (2.1%) and 157 female (10.5%). The incidence ranged from 15 to 38 cases in 300 patients of every department (5.0% Sofia to 12.7% Erfurt). 60.6% of the nickel positives were schoolgirls or younger than 25 years. The exposure time was 3 years, in 49% 1 year or shorter. Most cases (75%) are not occupationally acquired, but due to costume jewelry (31.8%), wrist watches (23.3%), metal clothing buckles (3.4%) including jeans buttons. Job dependent nickel dermatitis is often (36/51 cases) linked with wet work. Atopic dermatitis was found in 8.3% of female nickel allergy. Nickel positivity without a dermatitis history was seen in 9/176 cases (5%). Nickel allergy will become a sex-indifferent phenomenon in Europe, because of the changing customs of adornment.
SUMMARY
It has been known for many years that endocrine disorders have been found in women with rosacea. This disease is found more commonly in women who have menstrual abnormalities, or who are postmenopausal. There is, however, a paucity of adequate reports on the effect of simple hormonal therapy in the treatment of rosacea.
This has prompted a systematic, longterm study of the influence of an oral ovulation inhibitor, namely Ovosiston, on this unpleasant and unsightly disorder.
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