No abstract

In 1996, Bolhuis and Chowhan compiled a review of excipients that were used for the direct compaction of tablets. This article updates that review because since that time there has been considerable activity in this area. New single component and coprocessed filler-binders have been introduced. In addition, there have been advances in the understanding of how such substances act and hence how they can be optimally designed.

No abstract

The reduction in porosity of a powder bed on compression was found to be a function of the velocity of the punch of the press. Substances which consolidated principally by fragmentation showed relatively little velocity dependence. However, the more important deformation was in a powder's consolidation mechanism, the greater the dependence on punch velocity and hence tablet press speed.