The aim of the research was the investigation of prophylactic using the drug «Cycloferon». Influence of Cycloferon on acute respiratory viral infection and flu and on their clinical manifestations as well as on local immunity condition was assessed. We examined 124 children aged from 4 to 18 years. It was revealed that duration of acute respiratory viral infections as well as flu decreased and local immunity of the upper respiratory ways increased considerably in children taking Cycloferon. The abovementioned changes were observed both just after the treatment and in the follow-up period.
The ability of memory was investigated in 524 children, aged 4 to 7; with remote consequences of perinatal damage of the central nervous system (CNS). A weak memory ability was detected in 42% of children with dysfunctions of the general and fine motility and in 59% of children with impaired speech. Severe gestosis, anemia in pregnancy (stage II) and a delayed intrauterine fetal development were found to have a negative influence on memory shaping process.
Objective: to evaluate tolerability and efficacy of a complex of sanative measures in preschoolers with recurrent respiratory infections (RRIs). Materials and methods. This study included 63 preschool children aged between 4 and 7 years from Seversk. Children with RRIs (n = 44) were randomized into 2 groups. The experimental group comprised 22 children who received a complex of sanative measures (including thermotherapy, cold massage of the nasal vestibule, and breathing exercises), whereas the control group included 22 children with RRIs who received a similar complex of sanative measures, but without cold massage. We also examined 19 healthy children. During 9 months, we had been monitoring clinical efficacy of this complex by evaluating the frequency and duration of acute respiratory infections, calculating the epidemic efficiency index (EEI) and epidemic efficiency coefficient (EEC), and assessing morphofunctional characteristics of the nasal mucosa using the method developed by L.A. Matveeva. Results. The highest treatment efficacy was observed in the experimental group (EEI=1.39; EEC=28.2%). The assessment of morphofunctional characteristics of the nasal mucosa demonstrated a significant decrease in the mean level of neutrophil destruction and squamous epithelium destruction among children from the experimental group by the end of the third month (р < 0.001 and р = 0.031 respectively); these changes were stable and were still observed by the end of the 9th month (р = 0.001 and р = 0.030 respectively). We also registered a significant decrease in the neutrophil cytolysis index and squamous epithelium cytolysis index by the end of the 3rd month (р = 0.024 and р = 0.037 respectively). Comparative analysis showed a more pronounced reduction of the mean destruction rates of neutrophils and squamous epithelium along with cell cytolysis indices (for neutrophils and squamous epithelium) in the experimental group during 9 month of rehabilitation compared to the control group. Conclusion. The proposed complex of measures is well tolerated by patients, decrease the number of RRI episodes, and restore the components of the local immunity in the nasal mucosa; therefore, it can be used for the rehabilitation of preschoolers with RRIs. Key words: recurrent infections, children, non-pharmacological rehabilitation.
One of the most difficult categories of patients is patients with inflammatory bowel disease. A clinical case of the development of mesalazine-induced eosinophilic pneumonia in a 15-year-old boy with ulcerative colitis is presented. The patient suffered an acute respiratory disease, which caused the aggravation of ulcerative colitis and, accordingly, an increase in the dose of mesalazine. Against this background, the child had active complaints of heaviness in the chest to the left. Eosinophilia was noted in the blood. Analysis of clinical symptoms, X-ray data, microscopic examination of the pleural fluid, the results of spiral computed tomography of the chest allowed a differential diagnosis of the main symptoms and associated identified pulmonary lesions with mesalazine.
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