Introduction. The circadian rhythms of the nasociliary system of children with bronchial asthma have not been practically studied.Objective. To evaluate seasonal variations of circa-annual rhythms of the nasociliary system in healthy children and children with year-round bronchial asthma.Materials and methods. 134 children were examined; the main group consisted of 99 children aged 1.5–7 years with mild and moderate bronchial asthma, the control group was represented by 45 healthy children of the same age. The biorhythms of the nasociliary system were studied for three years, 4 times during each year (in October, January, April, July): smears-prints from the nasal mucosa were studied with the calculation of the specific gravity of neutrophils, eosinophils, cylindrical and squamous epithelium as a percentage, the calculation of the cytolysis index of cells and the average destruction index for each type of cell. To study the near-seasonal rhythms, the KOSINOR program and the computer system of intra-laboratory control “VlCC” were used.Results. The presence of seasonal changes in cytological parameters of the nasal mucosa with the maximum values of the average values of the average destruction of the flat, cylindrical epithelium, neutrophils in January and acrophases in January was revealed. If eosinophils on the nasal mucosa were not detected in healthy children, then the presence of this type of cells was noted in children with asthma throughout the year. The period of fluctuations of the average destruction index in the flat epithelium (1.7 months) was 4 times shorter, and in the cylindrical epithelium (21.6 months) – 3.5 times longer in children with asthma compared with healthy children. The periods, amplitude and mesor of the average neutrophil destruction index in children with asthma and healthy peers did not differ significantly. Acrophases and bathyphases of the average index of destruction of the flat, cylindrical epithelium, neutrophils in patients with asthma and healthy children were recorded at different times.Conclusions. The study showed that in children with AD there are no patterns of rhythmological organization in the work of the nasociliary system, characteristic of healthy children.
The aim of the study was to estimate the influence of rehabilitation measures on physical growth and cognitive functions in preschool children.We examined 224 children from 4 to 7 years old and in 197 (88%) of them revealed high level of health deviations. The most frequent were cervical insufficiency and bearing abnormality, of general and delicate motions, speech abnormalities. All children underwent cognitive functions checkup. In this connection we tilled the complex of rehabilitation measures for the children with physical growth and cognitive functions abnormalities. The efficacy of rehabilitation measures was estimated 3 years later.
The ability of memory was investigated in 524 children, aged 4 to 7; with remote consequences of perinatal damage of the central nervous system (CNS). A weak memory ability was detected in 42% of children with dysfunctions of the general and fine motility and in 59% of children with impaired speech. Severe gestosis, anemia in pregnancy (stage II) and a delayed intrauterine fetal development were found to have a negative influence on memory shaping process.
The clinical examination of 198 pregnant women after the health promotion program and their infants has been carried out. The content of stress hormones and the intensity of processes of lipid peroxidation have been studied, and adaptation abilities have been assessed. The use of the proposed rehabilitation program for pregnant women at early gestational ages favors the reduction of occurrence of feto-maternal disease and the increase of the adaptation reserve of women. Infants, whose mothers received the health promotional program, 3.5 times rarely had signs of the perinatal affection of the central nervous system.
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