The aim of the study is to determine the effects of low level laser therapy on tooth movement during canine distalization by evaluating IL-1β, TGF-β1 levels in gingival crevicular fluid. Maxillary first premolars of the 15 Angle Class II division I patients (12-19 years old) were extracted. Right maxillary canines were distalized by standard protocol as control group whereas the left maxillary canines distalized by laser application. A gallium-aluminum-arsenide diode laser with an output power of 20 mW was applied as five doses from the buccal and the palatal side on the day 0, and the 3rd, 7th, 14th, 21th 30th, 33st, 37th, 60th, 63th, and 67th days. Gingival crevicular fluid samples were obtained with filtration paper at the initial, 7th, 14th, and 21th days, and the IL-1ß and TGF-ß1 cytokine levels were analyzed. Orthodontic models and periodontal indices were taken initially and on the days 30th, 60th, and 90th of canine distalization period. Tooth movement was assessed by scanning models (3Shape). The amount of tooth movement in the laser group was 40% more than the control group. First day IL-1ß levels were statistically higher than initial and 21st day levels (P= 0.003, P = 0.012). The rise in IL-1ß levels caused the negative correlations between 7th day IL-1β and 21st day TGF-β1 levels describes the tissue effects of laser application. Periodontal indices showed no sign of gingival inflammation during canine distalization period. As conclusion, laser does accelerate tooth movement and could shorten the whole treatment duration.

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The purpose of this investigation was to study the short-term effects of treatment with the Bass appliance by comparative evaluation of treated and untreated skeletal Class II malocclusions. The subjects consisted of forty-seven Class II, division 1 malocclusion cases. Twenty-seven (14 girls, 13 boys) were treated with the Bass appliance for an average of 6 months. The remaining 20 cases (6 girls, 14 boys) served as a control. At the end of the 6 month treatment period the statistically significant treatment changes could be summarized as follows: the sagittal skeletal relationship was improved as a result of favourable growth responses in both the maxilla and the mandible. The overjet was reduced and the molar relationship was corrected as a result of the extended skeletal changes. Distal movement of the upper dentition was evident, with unchanged inclination of the maxillary incisors. Both anterior and posterior facial heights were increased without changes in the inclinations of the palatal and mandibular planes. No significant dental movement was observed in the mandible.

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