Alysicarpus vaginalis (L.) DC commonly known as Alyce clover, belongs to the botanical family Fabaceae. It is widely distributed in India, Pakistan, Sri Lanka , Africa and Australia. In India it is traditionally used by the tribals for diuretics, leprosy, pulmonary troubles and back pain. The present study aimed to evaluate the hepatoprotective activity of ethanol extract of A. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats. Liver injury was induced in rats by single oral administration of of NB (50 mg/kg bw). One days after NB induction, the rats were treated with ethanolic extract of A. vaginalis orally at the doses of 200 mg/kg bw daily for 30 days. Silymarin (25 mg/kg bw orally) was used as reference drug. After 30 days serum biochemical parameters, antioxidant enzyme status and histopathological parameters were analyzed. The results indicated that the ethanol extract of A. vaginalis the doses of 200 mg/kg orally significantly (P< 0.05) and dose-dependently reduced and normalized the serum marker enzymes, and increased the antioxidant enzyme status as compared to that of NB control group. Further more it was confirmed by histopathological studies. This study concludes that A. vaginalis demonstrated promising hepatoprotectivity agent in NB induced hepatic damaged rats.

Diabetes mellitus is a complex disorder that disturbs the metabolism of carbohydrates, fats, and proteins. Medicinal plants play an important role in the management of diabetes mellitus. The present study was aimed to evaluate the antidiabetic potential of Zaleya decandra roots on alloxan-induced diabetes in rats. Oral administration of ethanolic extract of the root (200 mg/kg body weight/day) for 15 days restored the levels of glucose, cholesterol, triglycerides, total proteins, urea, creatinine, lipid peroxidation level, and antioxidant enzymes significantly in diabetic rats. Histopathological studies showed significant changes like necrosis and degeneration in the liver and pancreas of alloxan-induced diabetic rats. Also these histopathological abnormalities were found to be normalized after treatment with Z. decandra extract. The efficacy of the root extract was found to be equivalent when compared to the standard hypoglycemic drug glibenclamide (1.25 mg/kg body weight/day, orally) in diabetic rats.

This study aimed to determine the phytochemical components, microbial inhibitory effectiveness and antioxidant properties of Aerva lanata plant extracts. The whole plant showed various medicinal applications in folklore and traditional medicine in various parts of the world. The organic extracts such as ethanol, ethyl acetate, chloroform, acetone, water and methanol were subjected for various phytochemical analysis and confirmed for the existence of flavonoids, glycosides, terpenoids and alkaloid containing components. Alternatively, the extracts were performed for the antibacterial activities against the microbial pathogens and antioxidant properties. Results indicated that, the solvent extracts showed prominent activity against the tested strains. The MIC concentrations of plant were detected from 5 mg/ml to 40 mg/ml. The plant extract was highly effective against E. coli and E. aerogenes and the MIC was 5 mg/ml. In addition, the extracts noted promising antioxidant activities. The antioxidant activities were dose dependent manner. In conclusion, A. lanata extracts showed that significant major phytochemicals and effective antioxidant and anti-microbial properties.

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The study was designed to evaluate the hepatoprotective activity of ethanolic extract of Bacopa monnieri in acute experimental liver injury induced by Nitrobenzene in rats. The extract at the dose of 200 mg/kg body weight was administered orally once every day for 10 days. The increased serum marker enzymes, Aspartate transaminase, Alanine transaminase and alkaline phosphatase were restored towards normalization significantly by the extract. Significant increase in SOD, CAT and GPx was observed in extract treated liver injured experimental rats. Histopathological examination of the liver tissues supported the hepatoprotection. It is concluded that the ethanolic extract of Bacopa monieri plant possess good hepatoprotective activity.