From well-known antioxidants agents, we developed a first pharmacophore model containing four common chemical features: one aromatic ring and three hydrogen bond acceptors. This model served as a template in virtual screening of Maybridge and NCI databases that resulted in selection of sixteen compounds. The selected compounds showed a good antioxidant activity measured by three chemical tests: DPPH radical, OH° radical, and superoxide radical scavenging. New synthetic compounds with a good correlation with the model were prepared, and some of them presented a good antioxidant activity.

Introduction: Primary hypertension can be masked and be responsible of a severe impact on the target bodies. The purpose of this study was to see if Phenobarbital at low dose is able to decrease the sympathetic hyperactivity assessed by cardiovascular autonomic reflexes in patients with masked hypertension. Materials and methods: This prospective study was conducted on a total of 91 patients with masked hypertension (average age 52.1 AE 10.3 years old). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of Phenobarbital, included deep breathing, hand-grip, mental stress and orthostatic tests. Statistical analysis was done using the Student's t-test, Univariate and Multivariate logistic regression analysis; p is significant if < 0.05. Results: Cardiovascular autonomic reflexes responses before and after 3 months of Phenobarbital oral administration were as follows: Vagal response (XDB) obtained on deep breathing test was of 32.6 AE 5.4% VS 30.4 AE 6.1%, (p ¼ 0.08), alpha peripheral sympathetic response (alpha SP) obtained on hand grip test was of 35.6 AE 8.7% VS 12.0 AE 2.5%, (p < 0.001), alpha central sympathetic response (alpha SC), beta central sympathetic response (beta SC) obtained during mental stress were of respectively 29.3 AE 9.2% VS 11.8 AE 2.4%, (p < 0.001) and 11.0 AE 5.3% VS 10.4 AE 6.1%, (p ¼ 0.2), alpha peripheral adrenergic sympathetic (alpha PAS) obtained during orthostatic test was of 25.3 AE 6.0% VS 13.0 AE 3.4%, (p < 0.001). Conclusion:These results demonstrated that Phenobarbital at low dose may have an anti-sympathetic effect in patients with masked hypertension.

Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was to evaluate both sympathetic and vagal activity responses in patients receiving amlodipine as antihypertensive agent. Patients and Methods. This prospective study included a group of primary hypertensive patients (N = 32, mean age 54.6 ± 7.6 years). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of amlodipine, included deep breathing, hand-grip, and mental stress tests. Statistical analysis was done using the Student's t-test. Results. Cardiovascular autonomic reflexes responses before and after 3 months of amlodipine oral administration were as follows: the mental stress test stimulation method produced a central alpha adrenergic response of 23.9 ± 8.7% versus 11.2 ± 2.0% (P < 0.05), a central beta sympathetic response of 16.7 ± 9.2% versus 10.4 ± 1.3% (P < 0.05), a blood pressure increase in response to hand grip test of 20.5 ± 7.3% versus 10.7 ± 2.4% (P < 0.05), vagal response to deep breathing test was 21.2 ± 6.5% versus 30.8 ± 2.9%, (P < 0.05). Conclusion. The results attest that amlodipine may have an anti-sympathetic effect.

Background: Dyspnea is a subjective symptom of asthma whose perception is characterized by an interindividual varia- bility. Poor dyspnea perception is usually associated with increased risk of exacerbation and may lead to inappropriate asth- ma management and under-treatment. We sought to identify factors associated with discrepancies between poor dyspnea perception and abnormal lung function in patients with moderate persistent asthma. Methodology: 65 patients, who attended their scheduled follow-up pulmonology consultation at Ibn Sina Hospital (Rabat - Morocco), underwent interrogation including modified Medical Research Council (mMRC) scale for dyspnea, physical examination and spirometry. Two groups, those with mMRC < 2 (poor dyspnea perceivers) and those with mMRC scale ≥ 2 were compared. Results: Poor dyspnea perception was found in 21 patients (32.3%). Associated factors were male sex (p : 0.03), low so- cio-economic income (p : 0.01), an onset of symptoms greater than 10 years (p : 0.01), BMI ≥ 25 Kg/m2 (p : 0.04) and depression (p : 0.04). Conclusion: The results revealed factors significantly associated with poor dyspnea perception despite an obstructive venti- latory disorder. These factors could usefully be considered to successfully manage asthma as well as the regular prescription of an objective test like spirometry. Keywords: Asthma; dyspnea perception; spirometry.

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