Autonomic dysregulation and phenobarbital in patients with masked primary hypertension

Bakkali, Mustapha El; Aboudrar, Souad; Dakka, Taoufiq; Benjelloun, H.

doi:10.1016/j.heliyon.2020.e03239

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Благоприятные терапевтические возможности курсового приема небольших доз фенобарбитала в течение 3 мес. в отношении коррекции симпатической гиперактивности у пациентов с маскированной АГ были показаны в недавно опубликованном зарубежном исследовании [27]. Проспективное наблюдение за 91 пациентом в возрасте от 25 до 76 лет (60,5% женщин и 39,5% мужчин, 2023;17(3):161-167 Практика средний возраст составил 52,1 ± 10,3 года) с установленной первичной маскированной АГ продемонстрировало, что ежедневное применение фенобарбитала в дозе 0,3-0,5 мг/кг массы тела пациента в течение 3 мес.…”

Section: профилактика и коррекция последствий стрессаunclassified

Simple and effective solutions in the correction of anxiety and stress

Shishkova

2023

Medicinskij sovet

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Acute and chronic stress conditions have an adverse effect on human health at any age and are related to the psychosocial risk factors for chronic non-communicable diseases, increasing the risk of occurrence and development of not only cardiovascular, but also other common diseases such as diabetes mellitus, obesity, broncho-obstructive diseases, ulcerative lesions of gastrointestinal tract, etc. The negative effect of stress on the human health is effectuated both through endogenous pathophysiological changes and through behavioural disorders such as physical inactivity, malnutrition, smoking, alcohol intake, etc. It has also been shown that psychosocial risk factors significantly aggravate the clinical course of existing diseases, significantly reduce adherence to treatment, worsen quality of life, increase the risk of disability and expenditures paid in the healthcare system in patients with chronic non-communicable diseases. Thus, acute and chronic stress have a negative effect on the physical, mental and emotional health, that's why the right choice of both preventive measures and timely management is very important. The combination of non-pharmaceutical effect, including training in stress resistance skills, proper response and emergency self-help in a stressful situation, with the prescription of effective pharmacological therapy can be considered as the optimal strategy. Valocordin® available in the form of drops or tablets represents a combination of low doses of phenobarbital with ethyl bromisovalerianate and plant components, which enhances the positive effects of the combination due to functional.

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Section: профилактика и коррекция последствий стрессаunclassified

Simple and effective solutions in the correction of anxiety and stress

Shishkova

2023

Medicinskij sovet

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“…ст.)) продемонстрировали, что применение фенобарбитала в малых дозах способствует достоверному снижению симпатической гиперактивности и ведет к купированию сердечнососудистой функциональной симптоматики с нормализацией уровня АД [41].…”

Section: Practiceunclassified

Stress and stress-induced disorders

Ebzeeva

Polyakova

2022

Medicinskij sovet

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Stress is one of the most significant and widespread medical and social problems in the world and it is the etiological factor in 80% of diseases. In the modern world any person is subject to the influence of stress, regardless of the age and gender differences, culture and social status. Stress is a non-specific reaction of the body to the extreme impact of various factors - stressors. As stressors can be: emotional, social, physical, informational and other factors. In functional and morphological terms, stress is manifests itself as a general adaptation syndrome which mobilizes the body’s resources in order to maintain homeostasis. Stress is characterized by staging. The early period of stress is manifested by transient anxiety, with a decrease in body resistance – it is the first stage of the adaptation syndrome. The second stage of stress is characterized by the functional tension of the body’s systems and adaptation to new conditions. In the case of prolonged stress, the body’s reaction becomes pathological, with the depletion of adaptive reserves and the failure of protective mechanisms. At this stage is increase a vulnerability to any stressors. There is a further violation of the consistency of vital functions, and persistent anxiety is formed. In overwhelming majority of cases, stress-induced anxiety is develop of psychovegetative syndrome. In the case when combined the strategies of coping (it is the second stage of the reaction to stress - the stage of resistance) with stress and if it is interrupted at an early stage, in such a way the somatic symptoms are also interrupted at the stage of autonomic dystonia syndrome. When the persistent stress is, we have a development of the third stage – exhaustion. And against the background of limited adaptive reactions, there is a psychosomatic pathology. The above determines the need for early detection of psychovegetative syndrome and its timely treatment. The optimal choice is the appointment of combined drugs for stress, which have anti-anxiety, sedative and hypnotic effects. The combination of phenobarbital and ethylbromisovalerinate is one of the highly effective and widely used for the relief of stressinduced anxiety and manifestations of autonomic dysfunction, reducing the risk of developing psychosomatic pathology.

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Autonomic dysregulation and phenobarbital in patients with masked primary hypertension

Cited by 2 publications

References 20 publications

Simple and effective solutions in the correction of anxiety and stress

Simple and effective solutions in the correction of anxiety and stress

Stress and stress-induced disorders

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