Introduction: The field of cancer nano therapeutics is quickly evolving, and it is being used to address a number of issues with traditional drug delivery techniques. The goal of this study was to find out more about the impact of novel bioactive Poria-loaded sun flowers nanoparticles (Poria Nps) as anti-carcinogenic agent for Ehrlich solid tumour (EST). Methods: A total number of 40 adult female mice were divided into 4 groups included control group, Poria Nps group, EST group, and EST treated with Poria Nps group. Results: EST induced toxicity, apoptosis and oxidative stress while treatments of EST with Poria Nps improved this alteration in kidney functions and structure. Moreover, Poria Nps could scavenge free radicals producing beneficial effects against EST induced renal toxicity through activation of oxidative stress and apoptosis. The constructed novel oral nanoparticles developed have promising features in vivo as well as a high level of safety for efficient cancer treatment. Conclusion: Poria cocos nanoparticles (Poria Nps) kill the cancer cells through apoptosis which thereby regulates the proliferation of cancer cells and inhibits its spread to other organs.
Thioacetamide (TAA), well-known as a toxic agent and has been reported to be nephrotoxic due to oxidative stress induction and proinflammatory markers increase. Curcumin has been shown in various studies to have antioxidant and anti-inflammatory properties. This study aimed to investigate the ameliorative effect of curcumin against TAA-induced kidney toxicity in rats. In this study, 28 male albino rats were used, and kidney toxicity was induced by intraperitoneal injection of TAA at a dose of 200mg/kg, twice a week for 8 weeks then the rats were treated with curcumin at a dose of 200mg/kg, orally, daily for 2 weeks. Kidney functions in all the experimental groups as well as oxidative stress (MDA), catalase (CAT), and superoxide dismutase (SOD) were determined. In addition, DNA damage and the expression status of both proinflammatory cytokine (TNFα) and proliferating cell nuclear antigen (PCNA) were evaluated. Further, light microscopic studies were performed on kidney specimens. Our results demonstrated that TAA had a nephrotoxic effect, as evidenced by significantly increase in kidney functions as well as substantially increase in renal MDA associated with reduction in CAT and SOD antioxidant enzymes compared to control group. The administration of curcumin ameliorates the oxidative stress and upregulate the antioxidant parameters. Further, a signification increases in DNA damage, TNFα, and PCNA expression was seen in TAA-group which was then alleviated by curcumin treatment. In conclusion, the ameliorative effect of curcumin could be attributed to its ability to minimize oxidative stress, renal cell injury, and cytokine release.
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