Objective. Cognitive impairment reduces quality of life and is related to vascular and neurodegenerative disorders. However, there is also a close relationship between these diseases and oxidative stress. Thus, the purpose of this study was to assess whether inflammation and oxidative damage are associated with low cognitive performance in the elderly with different housing conditions. Methods. The study groups consisted of 32 institutionalized and 25 noninstitutionalized Brazilian elderly subjects. Oxidative damage, inflammation markers, and cognitive function were evaluated. Results. The results demonstrated pronounced oxidative stress in the institutionalized elderly group, which also had a lower antioxidant status compared to noninstitutionalized subjects. High levels of proinflammatory cytokines were also observed in the institutionalized elderly. Furthermore, the raised levels of inflammatory markers were correlated with increased oxidative stress, and both were associated with low cognitive performance. However, based on multiple linear regression analysis, oxidative stress appears to be the main factor responsible for the cognitive decline. Conclusions. The findings suggest that individuals with lower antioxidant status are more vulnerable to oxidative stress, which is associated with cognitive function, leading to reduced life quality and expectancy.

Highlights Resilience during the pandemic is fundamental. COVID-19 created ecological adversities for child protective services workers. Importance and work support directly predict professionals’ resilient behavior.

Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.

The study aimed to explore mental distress during COVID-19 quarantine in a sample of university workers in Brazil. The survey included sets of questions about demographics, health, and support, an open question about major concerns, and the Clinical Outcome Routine Evaluation (CORE-OM), a measure of mental distress. A total of 407 professionals, mean age 40, SD 11.2, fulfilling social distancing (99%) participated in the study. Participants were mostly female (67.8%) and married (64.8%). Using the Consensual Qualitative Research process for simple qualitative data (CQR-M), the main areas of concern were grouped into six domains, as follows: work, health, isolation, personal life and routine, social environment, and future. Many responses were multiple. They form categories indicating specific concerns within these domains. Quantitative data were analyzed by identifying the simple effects of potential predictors of mental distress. The results indicated medium effects of help with household chores (η2 = 0.06, 95% confidence interval (CI) (0.022–0.095)), psychiatric treatment (η2 = 0.06, CI (0.030–0.110)), age (η2 = 0.12, CI (0.070–0.170)), and physical exercise (η2 = 0.12, CI (0.079–0.180)). Having someone available to listen was the only variable with a large effect associated with reduced mental suffering (η2 = 0.18; CI (0.118–0.227)). Psychological experiences of the pandemic are multifaceted and complex. Thus, substantially larger surveys, with both quantitative and qualitative components, are needed.

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This study investigated the relationship between measures of the Wisconsin Card Sorting Test (WCST)and a brief battery of cognitive functions (NEUPSILIN) with the goal of providing a better understanding of the association between executive processes and other functions. The sample included 39 people, from 14 to 61 years old, with an average education of 12.38 (SD = 3.65) years of study. The hypothesis that correlations would be moderate to strong between the measures of executive function, working memory, attention and prospective memory from NEUPSILIN and WCST scores was partially corroborated because the intensity of the correlations was below than the expected. Other correlations were also found between the WCST scores and tasks that assess semantic-episodic memory, oral language (inference processing) and writing (reading) components. Keywords: Executive functions, cognition, neuropsychology, WCST, NEUPSILIN. ResumoEste estudo investigou a relação entre medidas do WCST e de uma bateria breve de funções cognitivas (NEUPSILIN), com o objetivo de fornecer uma melhor compreensão sobre a associação entre processos executivos e demais funções. Participaram 39 pessoas entre 14 e 61 anos de idade e média de escolaridade de 12,38 (DP=3,65) anos de estudo. A hipótese de que correlações moderadas a fortes se dariam entre as medidas de funções executivas, memória de trabalho, atenção e memória prospectiva do NEUPSILIN e os escores no WCST foi parcialmente corroborada, porque a intensidade das correlações foi inferior ao previsto. Também foram encontradas correlações entre escores do WCST e tarefas que mensuram componentes de memória episódico-semântica, linguagem oral (processamento inferências) e escrita (leitura).

Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydratase (ALA-D), as well as to verify the influence of some metals in the enzyme activity and cognitive performance. Blood ALA-D activity, essential (Fe, Zn, Cu, Se) and non-essential metals (Pb, Cd, Hg, As, Cr, Ni, V) were measured in 50 elderly and 20 healthy young subjects. Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery and other. The elderly group presented decreased ALA-D activity compared to the young group. The index of ALA-D reactivation was similar to both study groups, but negatively associated with metals. The mean levels of essential metals were within the reference values, while the most toxic metals were above them in both groups. Cognitive function impairments were observed in elderly group and were associated with decreased ALA-D activity, with lower levels of Se and higher levels of toxic metals (Hg and V). Results suggest that the reduced ALA-D activity in elderly can be an additional factor involved in cognitive decline, since its inhibition throughout life could lead to accumulation of the neurotoxic compound ALA. Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation.

ResumoO desenvolvimento de normas para categorias semânticas é necessário para a compreensão do modo como os indivíduos organizam o conhecimento na memória e para a construção de instrumentos de avaliação cognitiva. O objetivo do presente estudo é fornecer normas associativas de 20 categorias semânticas para adultos e idosos brasileiros. Participaram do estudo 236 pessoas, entre 40 e 88 anos, das cinco regiões brasileiras. Os participantes responderam a um questionário de dados sociodemográficos e a um questionário de itens para categorias semânticas, e foram solicitados a produzir os cinco primeiros exemplares de cada categoria apresentada. Os resultados foram agrupados e são apresentadas as normas das categorias (exemplares, tamanho da categoria, respostas corretas, em branco e erros), bem como as respostas de cada categoria que foram comuns a todas as regiões brasileiras. Palavras-chave: semântica; normas; associação; adulto; idoso. Semantic association norms for 20 categories in adults and elderly AbstractThe development of semantic category norms is necessary to assist in the understanding of how individuals organize knowledge in memory, and to the creation of cognitive assessment instruments. The aim of this study is to provide associative norms of 20 semantic categories for Brazilian adults and elderly. The study included 236 participants from 40 to 88 years of age from the five Brazilian regions. They answered a socio-demographic questionnaire and a semantic category questionnaire, in which they were asked to produce the first five items of each category. Results are presented in category norms (items, category set size, correct responses, no responses and errors), as well as the responses that were common to all Brazilian regions belonging to each category.