The results of the study indicated that there is no relationship between the time of onset of pre-eclampsia and the placental changes that occur in these factors.
C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CHIT) is an enzyme of the chitinase class, which can hydrolyze chitin and various artificial substrates. The human CHIT gene is located on 1q31-q32, and contains a sequence of 20 kb, consisting of 12 exons. 1 CHIT enzymes are synthesized selectively in re-Chitotriosidase Activity in Normal Pregnancies and in Abortions A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. R Re es su ul lt ts s: : Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). C Co on nc cl lu us si io on n: : Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion. K Ke ey y W Wo or rd ds s: : Chitotriosidase; abortion, spontaneous Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızda normal ve abortus tanısı almış gebelerde maternal serum kitotriosidaz aktivitesini karşılaştırarak abortus öngörüsünde kitotriosidazın önemi hakkında bilgi edinilmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif vaka-kontrol çalışması olarak planlandı. Çalışma 10. gebelik haftasının altında olan 81 spontan abortus olgusu ve 61 normal gebe olmak üzere, toplam 142 gebelik olgusu üzerinde yapıldı. Spontan abortus grubundan beş gebe ve sağlıklı gebe grubundan bir gebe çalışma dışı bırakıldı. Bu gebelerden maternal periferik kan örneği alındı. Bu örneklerden fluorometri yöntemi ile kitotriosidaz aktivitesi belirlendi. B Bu ul lg gu ul la ar r: : Spontan abortus grubunda maternal serum kitotriosidaz aktivitesi, kontrol grubuna göre anlamlı şekilde yüksek bulundu (p<0,001). Maternal serum kitotriosidaz aktivitesi için 46 nmol/mL/saat eşik değerinin sensivitesi %53,9 ve spesifitesi %85 olarak saptandı. Abortus tipi ile kitotriosidaz aktivitesi arasında anlamlı bir fark bulunmadı (p>0,05). S So on nu uç ç: : Abortus patogenezinde aktive makrofajların rolü olabilir. Bu konuda ileri çalışmalara ihtiyaç vardır. Bu çalışma, spontan abortuslarda makr...
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