Five hundred sixty‐two cases of angioleiomyoma in our files on soft tissues were reappraised clinico‐pathologically. There was a preponderance in females with a ratio of 1.7:l. The angioleiomyoma could be separated into three histologic subtypes: capillary or solid (374 cases), cavernous (61 cases), and venous (127 cases) types. Five hundred (89%) occurrences were in the extremities, 48 in the head, and only 14 in the trunk. The tumors caused pain and/or tenderness in 327 cases, in which 262 were of the solid type. In 16 cases, small groups of mature fat cells were demonstrated within the tumor, suggesting the hamartomatous nature of these smooth muscle tumors.

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A type of gastric carcinoma was specified under the designation of carcinoma with lymphoid stroma. Grossly, this carcinoma was characterized by clear circumscription, usually with a central ulceration. A histologic feature distinguishing this carcinoma was the presence of a nandesmoplastic stroma infiltrated uniformly with an abundance of lymphocytes and plasma cells throughout the entire area of the tumor. Sparse population of less pleomorphic cancer cell nests of thin trabecular, microalveolar, or primitive tubular pattern widely separated by the intervening stroma was another feature peculiar to this tumor. Carcinoma of this type was found in 4% of a total of 1041 cases of gastric carcinoma removed surgically. A high survival rate was noted amon? the patients undergoing surgery for this carcinoma. A proposal was made on the separate classification of this tumor from common gastric carcinomas. Cancer 38232443, 1976. ANY ATTEMPTS HAVE BEEN MADE TO CORM relate the individual gross and microscopic features of a carcinoma with the post-operative survival rate of the patients.1,4-6j12-15924 Particular attention has been paid by a number of p;ithologists to the prognostic significance of the lymphocytic and other cellular reactions occuri ing in the tumor stroma.2~4~ 3,13*18,2n Moore and Foote specified medullary carcinoma with lymphoid infiltration of tlie breast, in view of its histologic peculiarity associated with a favorable postoperative prognoskZ1 Occurrence of a similar carcinoma in the stomach wa5 reported first by iMac-Carty et al. and later by several autliors.4-0, 1 1 ~ 2 ~ Emphasizing the histologic and pi-og

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Clinicopathologic, enzyme histochemical, and electron microscopic findings in 207 cases (208 lesions) of giant cell tumor of tendon sheath (GCTTS) are presented. The GCTTS could he divided into two groups according to the anatomic location, the first occurring in the digits (digit group, 182 cases) and the second, in the larger joints (large joint group, 25 cases). In the majority of cases of the digit group, the tumor occurred in one of the fingers (158 cases), whereas in the large joint group, the tumor was common in the ankle (10 cases) and knee joints (8 cases). The lesion was more common in women (67%) than in men (33%). Microscopically, the GCTTS in both groups consisted of a mixture of abundant histiocyte-like, foam, and multinucleated giant cells of the osteoclast type. However, worthy of special mention were the large clefts or wide pseudoglandular spaces lined by synovial cells and that were more striking in the large joint group than in the conventional digit group. The component cells had functional properties of macrophages, as determined in the enzyme histochemical study. Electron microscopically, the tumors consisted essentially of histiocyte-like, fibroblast-like, and intermediate cells, together with myofibroblasts.Cancer 57:875-884,1986.IANT CELL TUMOR of tendon sheath (GCTTS) (nod-G ular tenosynovitis) and pigmented villonodular synovitis (PVS) have long been studied. The conditions are considered to be benign growths of round or polygonal histiocyte-like cells associated with multinucleated giant cells, foam cells, and hemosiderin-laden cells. Although these two conditions are considered related entities, there is a practical difference. Most lesions of GCTTS produce one or more discrete nodules commonly on the tendon sheath or in the small joints of the fingers and toes. '-9 Less common sites include large joints, such as the ankle or knee PVS is identified by a diffusely proliferated synovial membrane bearing a villous aspect with or without nodular formation, and most frequently involves the knee joint. 2-1 Jaffe and associates,I6 who studied the histologic characteristics of these lesions, concluded that the lesions were in reality multiple manifestations of a single disease, including GCTTS (localized

The clinicopathologic and immunohistochemical features in 120 cases of gastrointestinal stromal tumor (GIST) were reviewed. Excluding 24 cases of gastric schwannoma, 96 cases of GIST consisting of 62 benign tumors and 34 sarcomas (low grade, 17; high grade, 17), with 9 cases arising in the esophagus, 57 in the stomach, 28 in the small intestine, and 2 in the colon, were studied. All esophagus and colon tumors were benign and resembled a conventional leiomyoma histologically. However, the gastric and small intestine benign tumors mostly showed histologic features of cellular or epithelioid leiomyoma. Immunohistochemically, desmin caused a positive reaction in all esophagus and colon tumors, but only 26% of gastric and small intestine tumors. However, muscle‐specific actin (HHF35) caused a positive reaction in most GIST (92%). The 10‐year survival rates of the patients with gastric sarcoma and those with intestinal sarcoma were 74% and 17%, respectively. These results showed that histologic and immunohistochemical features were distinctly different, depending on the location in the gastrointestinal tract; that most GIST, excluding schwannoma, had smooth muscle differentiation; and that sarcomas had a more favorable prognosis when they occurred in the stomach rather than the intestine. Cancer 1992; 69:947–955.

This clinicopathologic study concerns 63 instances of glomus tumor of the soft tissues. The tumors occurred at different ages but were more common in earlier adult life and most commonly occurred on the fingers (35 cases), frequently as subungual nodules (26 cases). Other sites of occurrence were the forearm in seven, the knee in seven, and the leg in six. All patients but one complained of pain. Histologically, the tumors, showing endothelium‐lined vascular spaces surrounded by masses of epithelioid cells, could be divided into three varieties: vascular (29 cases), myxoid (23 cases), and solid (11 cases). Under electron microscope the tumor cells in four cases proved to be smooth‐muscle cells. The clinicopathologic evidence presented supports the hypothesis that the glomus tumor is a tumor‐like lesion of mesodermal disorder rather than a true neoplasm.