Giant cell tumor of the tendon sheath (nodular tenosynovitis): A study of 207 cases to compare the large joint group with the common digit group

Abstract

Clinicopathologic, enzyme histochemical, and electron microscopic findings in 207 cases (208 lesions) of giant cell tumor of tendon sheath (GCTTS) are presented. The GCTTS could he divided into two groups according to the anatomic location, the first occurring in the digits (digit group, 182 cases) and the second, in the larger joints (large joint group, 25 cases). In the majority of cases of the digit group, the tumor occurred in one of the fingers (158 cases), whereas in the large joint group, the tumor was common in the ankle (10 cases) and knee joints (8 cases). The lesion was more common in women (67%) than in men (33%). Microscopically, the GCTTS in both groups consisted of a mixture of abundant histiocyte-like, foam, and multinucleated giant cells of the osteoclast type. However, worthy of special mention were the large clefts or wide pseudoglandular spaces lined by synovial cells and that were more striking in the large joint group than in the conventional digit group. The component cells had functional properties of macrophages, as determined in the enzyme histochemical study. Electron microscopically, the tumors consisted essentially of histiocyte-like, fibroblast-like, and intermediate cells, together with myofibroblasts.Cancer 57:875-884,1986.IANT CELL TUMOR of tendon sheath (GCTTS) (nod-G ular tenosynovitis) and pigmented villonodular synovitis (PVS) have long been studied. The conditions are considered to be benign growths of round or polygonal histiocyte-like cells associated with multinucleated giant cells, foam cells, and hemosiderin-laden cells. Although these two conditions are considered related entities, there is a practical difference. Most lesions of GCTTS produce one or more discrete nodules commonly on the tendon sheath or in the small joints of the fingers and toes. '-9 Less common sites include large joints, such as the ankle or knee PVS is identified by a diffusely proliferated synovial membrane bearing a villous aspect with or without nodular formation, and most frequently involves the knee joint. 2-1 Jaffe and associates,I6 who studied the histologic characteristics of these lesions, concluded that the lesions were in reality multiple manifestations of a single disease, including GCTTS (localized

Malignant Giant Cell Tumor in the Carpal Tunnel: A Case Report and Review of Literature

“…Only 37 malignant tenosynovial GCTs have been reported in the literature since 1979, and these are summarized in ►Tables 1-3. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Of these 37 patients, follow-up outcome was known in 30 patients; one patient had died of other causes (DOC). Of the remaining 29 patients, 11 patients died of disease (DOD), 4 patients were living with disease (LWD) and 14 patients had no evidence of disease (NED) since their last treatment, with a follow-up of 6 months to 49 years.…”

Tumor de células gigantes de bainha de tendão no LCA

“…Some authors suggest that this disease is resultant from a lipid metabolism change, inflammation or benign neoplasic process (11) . The potential of this disease being induced by trauma is described; Rodrigues et al found a prevalence of previous trauma in 21% of patients with GCTTS (1,2,5) . The clinical and X-ray-based diagnosis of GCTTS is difficult, because anamnesis, physical examination and X-ray data are unspecific, requiring the establishment of differential diagnoses of potential causes for knee arthralgia.…”

Acral manifestations of soft tissue tumors

“…Typically, a conservative excision with a surrounding rim of normal tissue is adequate. 4,19,24,34,35 Vascular and related tissues…”